Laboratory abnormalities in children with novel Coronavirus Disease 2019.

IF 1.7 Q2 PEDIATRICS

Clinical Medicine Insights-Pediatrics Pub Date : 2020-09-11 eCollection Date: 2020-01-01 DOI:10.1177/1179556520955177

Laila Bourkhissi, Karima El Fakiri, Houda Nassih, Rabiy El Qadiry, Aicha Bourrahouat, Imane Ait Sab, Noureddine Rada, Ghizlane Draiss, Mohammed Bouskraoui

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引用次数: 21

Abstract

The novel Coronavirus disease 2019 continues to be a worldwide pandemic. Yet, little is still known about the biological features of this emergent infection in children. In this prospective study, we collected 68 children infected with SARS-COV-2 from March 2020 to May 2020, in Marrakesh, Morocco. No severe cases were observed in this cohort, and 66% of the patients were asymptomatic. The main laboratory abnormalities were hematological, as we found Leucopoenia in 4.4% of the cases, hyperleukocytosis in 1.6%. Neutropenia was found in 5 patients (7%) and only 2 cases (3%) had Lymphopenia. The inflammation and coagulation biomarkers were normal in the majority of the cases, as for liver and kidney function. Lactate dehydrogenase (LDH) serum levels were elevated in 8 cases (11.67%). The COVID-19 in children seems to have mild course and better outcome than in adults, which impacts the laboratory findings in this category. More studies must be conducted to learn more about the laboratory abnormalities in pediatric COVID-19.

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2019年新型冠状病毒病儿童的实验室异常

2019年新型冠状病毒病继续成为全球大流行。然而，对这种儿童突发感染的生物学特征仍然知之甚少。在这项前瞻性研究中，我们收集了2020年3月至2020年5月在摩洛哥马拉喀什感染SARS-COV-2的68名儿童。在该队列中未观察到严重病例，66%的患者无症状。主要的实验室异常为血液学异常，我们发现白细胞减少率为4.4%，白细胞增多率为1.6%。中性粒细胞减少5例(7%)，淋巴细胞减少2例(3%)。大多数病例的炎症和凝血生物标志物正常，肝肾功能正常。血清乳酸脱氢酶升高8例(11.67%)。与成人相比，儿童中的COVID-19似乎病程较轻，预后较好，这影响了这一类别的实验室结果。必须进行更多的研究，以更多地了解儿童COVID-19的实验室异常情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Medicine Insights-Pediatrics PEDIATRICS-

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8 weeks