Use of Growth Hormone Treatment in Skeletal Dysplasia - A Review.

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2020-08-01 DOI:10.17458/per.vol17.2020.kc.ghtreatmentskeletaldysplasia

Inderpal Singh Kochar, Rashim Chugh

引用次数: 3

Abstract

Skeletal dysplasias are the disorders of the skeletal and cartilaginous tissues. Short stature is the hallmark presentation. Achondroplasia is the commonest skeletal dysplasia. Growth hormone (GH) has been widely used in children with achondroplasia. Various studies have shown 1st year increase in height velocity is about 2-3cm. Apart from achondroplasia, studies have also shown positive effect of GH in hypochondroplasia children. However, in hypochondroplasia GH treatment seems to give better results when administered at puberty. Other forms of skeletal dysplasias are rare, so no conclusion on GH use in such patients can be drawn.

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生长激素治疗骨骼发育不良的应用综述。

骨骼发育不良是骨骼和软骨组织的紊乱。身材矮小是典型的表现。软骨发育不全是最常见的骨骼发育不良。生长激素(GH)已广泛应用于软骨发育不全儿童。各种研究表明，第一年身高速度增加约2-3cm。除了软骨发育不全外，研究也表明生长激素对软骨发育不全儿童有积极作用。然而，在软骨发育不良中，生长激素治疗似乎在青春期给予更好的结果。其他形式的骨骼发育不良是罕见的，所以对这类患者使用生长激素没有结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.