West Nile Virus-Induced Neurologic Sequelae-Relationship to Neurodegenerative Cascades and Dementias.

IF 3.6 Q2 INFECTIOUS DISEASES

Current Tropical Medicine Reports Pub Date : 2020-03-01 Epub Date: 2020-02-18 DOI:10.1007/s40475-020-00200-7

Amy Y Vittor, Maureen Long, Paramita Chakrabarty, Lauren Aycock, Vidya Kollu, Steven T DeKosky

{"title":"West Nile Virus-Induced Neurologic Sequelae-Relationship to Neurodegenerative Cascades and Dementias.","authors":"Amy Y Vittor, Maureen Long, Paramita Chakrabarty, Lauren Aycock, Vidya Kollu, Steven T DeKosky","doi":"10.1007/s40475-020-00200-7","DOIUrl":null,"url":null,"abstract":"Purpose of review: West Nile virus (WNV) emerged from Central Africa in the 1990s and is now endemic throughout much of the world. Twenty years after its introduction in the USA, it is becoming apparent that neurological impairments can persist for years following infection. Here, we review the epidemiological data in support of such long-term deficits and discuss possible mechanisms that drive these persistent manifestations.Recent findings: Focusing on the recently discovered antimicrobial roles of amyloid and alpha-synuclein, we connect WNV late pathology to overlapping features encountered in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. We also summarize new research on microglial activation and engulfment of neural synapses seen in recovered WNV as well as in neurodegenerative diseases, and discuss how loss of integrity of the blood-brain barrier (BBB) may exacerbate this process.Summary: Neuroinvasive viral infections such as WNV may be linked epidemiologically and mechanistically to neurodegeneration. This may open doors to therapeutic options for hitherto untreatable infectious sequelae; additionally, it may also shed light on the possible infectious etiologies of age-progressive neurodegenerative dementias.","PeriodicalId":37441,"journal":{"name":"Current Tropical Medicine Reports","volume":"7 1","pages":"25-36"},"PeriodicalIF":3.6000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40475-020-00200-7","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Tropical Medicine Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40475-020-00200-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/2/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 15

Abstract

Purpose of review: West Nile virus (WNV) emerged from Central Africa in the 1990s and is now endemic throughout much of the world. Twenty years after its introduction in the USA, it is becoming apparent that neurological impairments can persist for years following infection. Here, we review the epidemiological data in support of such long-term deficits and discuss possible mechanisms that drive these persistent manifestations.

Recent findings: Focusing on the recently discovered antimicrobial roles of amyloid and alpha-synuclein, we connect WNV late pathology to overlapping features encountered in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. We also summarize new research on microglial activation and engulfment of neural synapses seen in recovered WNV as well as in neurodegenerative diseases, and discuss how loss of integrity of the blood-brain barrier (BBB) may exacerbate this process.

Summary: Neuroinvasive viral infections such as WNV may be linked epidemiologically and mechanistically to neurodegeneration. This may open doors to therapeutic options for hitherto untreatable infectious sequelae; additionally, it may also shed light on the possible infectious etiologies of age-progressive neurodegenerative dementias.

查看原文本刊更多论文

西尼罗河病毒诱导的神经系统后遗症-与神经退行性级联和痴呆的关系。

审查目的:西尼罗河病毒(WNV)于20世纪90年代出现在中非，现在在世界大部分地区流行。在它被引入美国20年后，越来越明显的是，神经损伤可以在感染后持续数年。在这里，我们回顾了支持这种长期缺陷的流行病学数据，并讨论了驱动这些持续表现的可能机制。最近的发现:关注最近发现的淀粉样蛋白和α -突触核蛋白的抗菌作用，我们将西尼罗河病毒的晚期病理与阿尔茨海默病和帕金森病等神经退行性疾病的重叠特征联系起来。我们还总结了在恢复的西尼罗河病毒和神经退行性疾病中看到的小胶质细胞激活和神经突触吞噬的新研究，并讨论了血脑屏障完整性的丧失如何加剧这一过程。摘要:神经侵入性病毒感染，如西尼罗河病毒，可能与神经退行性变有流行病学和机制上的联系。这可能为迄今无法治愈的传染性后遗症提供治疗选择;此外，它也可能揭示了可能的感染性病因的年龄进行性神经退行性痴呆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Tropical Medicine Reports Medicine-Infectious Diseases

CiteScore

9.30

自引率

1.90%

发文量

期刊介绍： Current Tropical Medicine Reports provides expert views on recent advances in the field of tropical medicine in a clear and readable form. This journal offers reviews by domestic and international contributors that highlight the most important, recent papers and findings related to this specific field. We accomplish this by appointing renowned leaders in major tropical medicine subject areas to select topics addressing virology, bacteriology, parasitology, entomology, immunology, cell and molecular biology, epidemiology, ecology, behavioral science and clinical medicine for review by experts who assess the latest developments and highlight significant papers published over the last few years on their topics. These review articles also stress recently published papers of importance in the references, which are accompanied by annotations explaining their importance. In addition to these Section Editors, our international Editorial Board ensures our journal upholds its standards.