Epidemiologic, humanistic and economic burden of hepatocellular carcinoma in the USA: a systematic literature review.

IF 1.2 Q4 ONCOLOGY

Hepatic Oncology Pub Date : 2020-07-21 DOI:10.2217/hep-2020-0024

Abdalla Aly, Sarah Ronnebaum, Dipen Patel, Yunes Doleh, Fernando Benavente

引用次数: 33

Abstract

Aim: To describe the epidemiologic, humanistic and economic burdens of hepatocellular carcinoma (HCC) in the USA.

Materials & methods: Studies describing the epidemiology and economic burden from national cohorts, any economic models, or any humanistic burden studies published 2008-2018 were systematically searched.

Results: HCC incidence was 9.5 per 100,000 person-years in most recent data, but was ∼100-times higher among patients with hepatitis/cirrhosis. Approximately a third of patients were diagnosed with advanced disease. Patients with HCC experienced poor quality of life. Direct costs were substantial and varied based on underlying demographics, disease stage and treatment received. Between 25-77% of patients did not receive surgical, locoregional or systemic treatment.

Conclusion: Better treatments are needed to extend survival and improve quality of life for patients with HCC.

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美国肝细胞癌的流行病学、人文和经济负担：一项系统的文献综述。

目的：描述美国肝细胞癌（HCC）的流行病学、人文和经济负担。材料与方法：系统检索2008-2018年发表的描述全国人群流行病学和经济负担的研究、任何经济模型或任何人文负担研究。结果：在最近的数据中，HCC的发病率为每100000人-年9.5例，但在肝炎/肝硬化患者中高出约100倍。大约三分之一的患者被诊断为晚期疾病。HCC患者的生活质量较差。直接费用是巨大的，并且根据潜在的人口统计、疾病阶段和接受的治疗而有所不同。25-77%的患者没有接受手术、局部或全身治疗。结论：需要更好的治疗来延长HCC患者的生存期并提高其生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatic Oncology ONCOLOGY-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Primary liver cancer is the sixth most common cancer in the world, and the third most common cause of death from malignant disease. Traditionally more common in developing countries, hepatocellular carcinoma is becoming increasingly prevalent in the Western world, primarily due to an increase in hepatitis C virus infection. Emerging risk factors, such as non-alcoholic fatty liver disease and obesity are also of concern for the future. In addition, metastatic tumors of the liver are more common than primary disease. Some studies report hepatic metastases in as many as 40 to 50% of adult patients with extrahepatic primary tumors. Hepatic Oncology publishes original research studies and reviews addressing preventive, diagnostic and therapeutic approaches to all types of cancer of the liver, in both the adult and pediatric populations. The journal also highlights significant advances in basic and translational research, and places them in context for future therapy. Hepatic Oncology provides a forum to report and debate all aspects of cancer of the liver and bile ducts. The journal publishes original research studies, full reviews and commentaries, with all articles subject to independent review by a minimum of three independent experts. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.