Effect of augmented glycation in mobilization of plasma free fatty acids in type 2 diabetes mellitus.

IF 3.4

Diabetes & metabolic syndrome Pub Date : 2020-09-01 Epub Date: 2020-07-18 DOI:10.1016/j.dsx.2020.07.028

Kailash Chandra, Vineet Jain, Masood Azhar, Washim Khan, Ozair Alam, Sayeed Ahmad, Swatantra Kumar Jain

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引用次数: 3

Abstract

Background and aims: Type 2 Diabetes Mellitus (T2DM) is known to be associated with an increase in total plasma free fatty acid (FFA) concentration. The present study was conducted to determine the changes in plasma fatty acids at different levels of glycation in type 2 diabetes mellitus.

Methods: The study involved 50 subjects having different levels of glycation (HbA1c 4.9-15.0%) and further categorized in 5 groups [group 1 (HbA1c <6%), group 2 (HbA1c 6-7%), group 3 (HbA1c 7.1-9%), group 4 (HbA1c (9.1-12%) and group 5 (HbA1c >12%)] with 10 subjects in each group.

Results: A total of 19 free fatty acids were detected by gas chromatography-mass spectrometry (GC-MS) analysis in the plasma samples. The levels of lauric acid (C12:0) and stearic acid (C18:0) were significantly raised at an advanced stage of glycation (HbA1c 9.1-15%). Long-chain fatty acids, pentadecanoic acid (C15:0) and palmitic acid (C16:0) levels were elevated in hyperglycemia as compared to normoglycaemic subjects (HbA1c <6%). Moreover, levels of mono and polyunsaturated fatty acids, oleic acid (C18:1) and linoleic acid (C18:2, w6) were significantly decreased in patients with increased levels of glycation (HbA1c 6-15%).

Conclusion: GC-MS is a novel way to study the plasma fatty acid profiling and findings of this study suggest that monitoring alterations in plasma FFA profile may be of prognostic value.

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糖基化增强对2型糖尿病血浆游离脂肪酸动员的影响。

背景和目的:2型糖尿病(T2DM)与血浆游离脂肪酸(FFA)浓度升高有关。本研究旨在确定2型糖尿病不同糖基化水平下血浆脂肪酸的变化。方法:纳入50例不同糖化水平(HbA1c 4.9 ~ 15.0%)的受试者，分为5组[1组(HbA1c 12%)]，每组10例。结果:采用气相色谱-质谱(GC-MS)分析方法，在血浆样品中检出19种游离脂肪酸。月桂酸(C12:0)和硬脂酸(C18:0)水平在糖化晚期(HbA1c 9.1-15%)显著升高。长链脂肪酸、五酸(C15:0)和棕榈酸(C16:0)水平在高血糖组较血糖正常组升高。结论:气相色谱-质谱是研究血浆脂肪酸谱的一种新方法，本研究结果表明监测血浆FFA谱的变化可能具有预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & metabolic syndrome

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