Personalized TMS: role of RNA genotyping.

IF 9 Q1 PSYCHIATRY
Mental Illness Pub Date : 2019-01-01 Epub Date: 2019-11-04 DOI:10.1108/MIJ-10-2019-0004
Shawna Chan, Robert Bota
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引用次数: 2

Abstract

Purpose: Noninvasive brain stimulation (NIBS) such a transcranial magnetic stimulation, intermittent theta burst stimulation, transcranial direct current stimulation and electroconvulsive therapy have emerged as an efficacious and well-tolerated therapy for treatment-resistant psychiatric disorders. While novel NIBS techniques are an exciting addition to the current repertoire of neuropsychiatric therapies, their success is somewhat limited by the wide range of treatment responses seen among treated patients.

Design/methodology/approach: In this study, the authors will review the studies on relevant genetic polymorphisms and discuss the role of RNA genotyping in personalizing NIBS.

Findings: Genome studies have revealed several genetic polymorphisms that may contribute for the heterogeneity of treatment response to NIBS where the presence of certain single nucleotide polymorphisms (SNPs) are associated with responders versus nonresponders.

Originality/value: Historically, mental illnesses have been arguably some of the most challenging disorders to study and to treat because of the degree of biological variability across affected individuals, the role of genetic and epigenetic modifications, the diversity of clinical symptomatology and presentations and the interplay with environmental factors. In lieu of these challenges, there has been a push for personalized medicine in psychiatry that aims to optimize treatment response based on one's unique characteristics.

个性化TMS: RNA基因分型的作用。
目的:无创脑刺激(NIBS)如经颅磁刺激、间歇性θ波爆发刺激、经颅直流电刺激和电休克治疗已成为治疗难治性精神疾病的一种有效且耐受性良好的治疗方法。虽然新的NIBS技术是当前神经精神疗法的一个令人兴奋的补充,但它们的成功在一定程度上受到治疗患者治疗反应范围的限制。设计/方法/方法:本研究将回顾相关基因多态性的研究,并讨论RNA基因分型在NIBS个性化中的作用。研究结果:基因组研究揭示了几种遗传多态性可能导致NIBS治疗反应的异质性,其中某些单核苷酸多态性(snp)的存在与应答者和无应答者相关。独创性/价值:从历史上看,精神疾病可以说是研究和治疗最具挑战性的疾病之一,因为受影响个体的生物学变异性程度、遗传和表观遗传修饰的作用、临床症状和表现的多样性以及与环境因素的相互作用。面对这些挑战,精神病学一直在推动个性化医疗,旨在根据患者的独特特征优化治疗反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mental Illness
Mental Illness PSYCHIATRY-
CiteScore
1.10
自引率
0.00%
发文量
3
审稿时长
10 weeks
期刊介绍:
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