Endothelial Dysfunction, a Marker of Atherosclerosis, Is Independent of Metabolic Syndrome in NAFLD Patients.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

International Journal of Hepatology Pub Date : 2020-07-17 eCollection Date: 2020-01-01 DOI:10.1155/2020/1825142

Jimmy Narayan, Haribhakti Seba Das, Preetam Nath, Ayaskanta Singh, Debakanta Mishra, Pradeep Kumar Padhi, Shivaram Prasad Singh

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引用次数: 8

Abstract

Background: The study was designed to assess cardiovascular risk factors flow-mediated dilatation % (FMD%) and carotid intima-media thickness (CIMT) in NAFLD.

Methods: 126 NAFLD subjects and 31 chronic hepatitis B (CHB) controls were studied. Measuring carotid intima-media thickness (CIMT) and the flow-mediated dilatation % (FMD%) by brachial artery Doppler ultrasound were used to assess atherosclerosis. The risk of cardiac events at 10 years (ROCE 10) was estimated by the Prospective Cardiovascular Munster Study (PROCAM) score.

Results: 58 of 126 NAFLD have coexistent metabolic syndrome. Mean CIMT was 0.73 ± 0.041 mm among NAFLD with MS, 0.66 ± 0.016 mm among NAFLD without MS, and 0.66 ± 0.037 in controls CHB patients. FMD% in NAFLD with MS was 10.43 ± 3.134%, but was 8.56 ± 3.581% in NAFLD without MS and 17.78 ± 6.051% in controls. PROCAM score of NAFLD with MS was 46.95 ± 6.509 while in NAFLD without MS was 38.2 ± 3.738. Controls had a PROCAM score of 38.13 ± 5.755. ROCE 10 in NAFLD with MS was 13.64 ± 8.568 while NAFLD without MS was 5.55 ± 1.949. Controls have a ROCE 10 of 5.95 ± 3.973. Post hoc analysis showed CIMT was dependent upon MS while FMD% was different between all subgroups hence independent of metabolic syndrome.

Conclusion: The markers of endothelial dysfunction are significantly higher in patients with NAFLD than controls.

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内皮功能障碍是动脉粥样硬化的标志，与NAFLD患者的代谢综合征无关。

背景:本研究旨在评估NAFLD的心血管危险因素血流介导扩张% (FMD%)和颈动脉内膜-中膜厚度(CIMT)。方法:对126例NAFLD患者和31例慢性乙型肝炎(CHB)对照组进行研究。采用肱动脉多普勒超声测量颈动脉内膜-中膜厚度(CIMT)和血流介导扩张% (FMD%)评估动脉粥样硬化。10年心脏事件的风险(ROCE 10)通过前瞻性心血管明斯特研究(PROCAM)评分来估计。结果:126例NAFLD中58例合并代谢综合征。伴有MS的NAFLD患者的平均CIMT为0.73±0.041 mm，无MS的NAFLD患者的平均CIMT为0.66±0.016 mm，对照组CHB患者的平均CIMT为0.66±0.037 mm。NAFLD合并MS组FMD%为10.43±3.134%，非MS组为8.56±3.581%，对照组为17.78±6.051%。伴有MS的NAFLD的PROCAM评分为46.95±6.509，无MS的NAFLD的PROCAM评分为38.2±3.738。对照组的PROCAM评分为38.13±5.755。伴有MS的NAFLD的ROCE 10为13.64±8.568，无MS的NAFLD的ROCE 10为5.55±1.949。对照组ROCE 10为5.95±3.973。事后分析显示，CIMT依赖于MS，而FMD%在所有亚组之间不同，因此独立于代谢综合征。结论:NAFLD患者内皮功能障碍指标明显高于对照组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.