{"title":"A Comprehensive Update on Intestinal- and Non-Intestinal-Type Adenocarcinomas.","authors":"Vincent Vander Poorten, Mark Jorissen","doi":"10.1159/000457934","DOIUrl":null,"url":null,"abstract":"<p><p>This review of sinonasal adenocarcinoma, both intestinal and non-intestinal type, aims at providing a comprehensive overview of etiological factors, diagnostic workup, histological subtypes, advances in molecular characterization and the genetic basis, current optimal treatment strategies, resulting oncological outcome, and prognostic factors modifying the final treatment results. The current treatment of choice remains surgical resection with a curative intent, using the least invasive approach that allows for removal of the entire tumor with negative margins, supplemented with postoperative high-quality intensity-modulated radiotherapy in the majority of patients. To date, chemotherapy remains reserved for the palliative setting. The progress in understanding the underlying molecular biological mechanisms has not yet translated into standard of care applications.</p>","PeriodicalId":39848,"journal":{"name":"Advances in Oto-Rhino-Laryngology","volume":"84 ","pages":"137-153"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Oto-Rhino-Laryngology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000457934","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/7/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
Abstract
This review of sinonasal adenocarcinoma, both intestinal and non-intestinal type, aims at providing a comprehensive overview of etiological factors, diagnostic workup, histological subtypes, advances in molecular characterization and the genetic basis, current optimal treatment strategies, resulting oncological outcome, and prognostic factors modifying the final treatment results. The current treatment of choice remains surgical resection with a curative intent, using the least invasive approach that allows for removal of the entire tumor with negative margins, supplemented with postoperative high-quality intensity-modulated radiotherapy in the majority of patients. To date, chemotherapy remains reserved for the palliative setting. The progress in understanding the underlying molecular biological mechanisms has not yet translated into standard of care applications.
期刊介绍：
Material for each volume in this series has been skillfully selected to document the most active areas of otorhinolaryngology and related specialties, such as neuro-otology and oncology. The series reproduces results from basic research and clinical studies pertaining to the pathophysiology, diagnosis, clinical symptoms, course, prognosis and therapy of a variety of ear, nose and throat disorders. The numerous papers correlating basic research findings and clinical applications are of immense value to all specialists engaged in the ongoing efforts to improve management of these disorders. Acting as a voice for its field, the series has also been instrumental in developing subspecialities into established specialities.
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