{"title":"Correlation between C-reactive Protein with Malondialdehyde in Systemic Lupus Erythematosus Patients.","authors":"Nur Atik, S Putri Pratiwi, Laniyati Hamijoyo","doi":"10.1155/2020/8078412","DOIUrl":null,"url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus registry data, and MDA levels were analyzed from a bioarchive patient's serum. We collected the patients' data who had CRP level from Hasan Sadikin lupus registry and analysed MDA levels from the serum sample. MDA levels were analyzed using an ELISA method. The data obtained were analyzed using the Pearson correlation and Eta correlation test. The study involved 78 data patients as subjects. It was found that the median of CRP and MDA was 0.85 mg/l and 153.10 ng/ml, respectively. These results indicate that the CRP levels in SLE patients are still within normal limits. Statistical analysis showed no correlation between CRP and MDA level (<i>r</i> = 0.2, <i>P</i> > 0.05). Additionally, the correlation between CRP and MDA with organ involvement, such as lupus nephritis (LN), lupus cutaneous (LC), and lupus musculoskeletal (LM), showed no correlation (<i>F</i> <sub>h</sub> < <i>F</i> <sub>t</sub>). There is no correlation between CRP and MDA levels in SLE patients, and specific organ involvement of the disease does not affect the correlation.</p>","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8078412","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2020/8078412","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 4
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus registry data, and MDA levels were analyzed from a bioarchive patient's serum. We collected the patients' data who had CRP level from Hasan Sadikin lupus registry and analysed MDA levels from the serum sample. MDA levels were analyzed using an ELISA method. The data obtained were analyzed using the Pearson correlation and Eta correlation test. The study involved 78 data patients as subjects. It was found that the median of CRP and MDA was 0.85 mg/l and 153.10 ng/ml, respectively. These results indicate that the CRP levels in SLE patients are still within normal limits. Statistical analysis showed no correlation between CRP and MDA level (r = 0.2, P > 0.05). Additionally, the correlation between CRP and MDA with organ involvement, such as lupus nephritis (LN), lupus cutaneous (LC), and lupus musculoskeletal (LM), showed no correlation (Fh < Ft). There is no correlation between CRP and MDA levels in SLE patients, and specific organ involvement of the disease does not affect the correlation.
系统性红斑狼疮(SLE)是一种以炎症过程为特征的系统性自身免疫性疾病。可以测量的炎症标志物之一是c反应蛋白(CRP)。炎症的另一个指标是丙二醛(MDA),尽管它在SLE患者中仍然不常见。该研究寻找了MDA值,并发现了与CRP的相关性。进行了相关分析的横断面研究设计。CRP水平数据来自Hasan Sadikin狼疮登记数据,MDA水平分析来自生物档案患者的血清。我们从Hasan Sadikin狼疮登记处收集了CRP水平的患者数据,并分析了血清样本中的MDA水平。采用ELISA法分析MDA水平。采用Pearson相关检验和Eta相关检验对所得数据进行分析。该研究涉及78名数据患者作为研究对象。CRP和MDA的中位数分别为0.85 mg/l和153.10 ng/ml。这些结果表明,SLE患者CRP水平仍在正常范围内。经统计学分析,CRP与MDA水平无相关性(r = 0.2, P > 0.05)。此外,CRP和MDA与器官受累的相关性,如狼疮肾炎(LN)、狼疮皮肤(LC)和狼疮肌肉骨骼(LM),均无相关性(F h < F t)。SLE患者CRP与MDA水平无相关性,疾病特异性器官受累不影响相关性。