Regulation of blood flow in diabetic retinopathy.

IF 1.1 4区医学 Q4 NEUROSCIENCES

Visual Neuroscience Pub Date : 2020-07-20 DOI:10.1017/S0952523820000036

Amy R Nippert, Eric A Newman

引用次数: 8

Abstract

Blood flow in the retina increases in response to light-evoked neuronal activity, ensuring that retinal neurons receive an adequate supply of oxygen and nutrients as metabolic demands vary. This response, termed "functional hyperemia," is disrupted in diabetic retinopathy. The reduction in functional hyperemia may result in retinal hypoxia and contribute to the development of retinopathy. This review will discuss the neurovascular coupling signaling mechanisms that generate the functional hyperemia response in the retina, the changes to neurovascular coupling that occur in diabetic retinopathy, possible treatments for restoring functional hyperemia and retinal oxygen levels, and changes to functional hyperemia that occur in the diabetic brain.

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糖尿病视网膜病变的血流调节。

视网膜内的血流量随着光引起的神经元活动而增加，确保视网膜神经元在代谢需求变化时获得足够的氧气和营养供应。这种反应被称为“功能性充血”，在糖尿病视网膜病变中被破坏。功能性充血的减少可能导致视网膜缺氧，并有助于视网膜病变的发展。本文将讨论在视网膜中产生功能性充血反应的神经血管耦合信号机制，糖尿病视网膜病变中发生的神经血管耦合变化，恢复功能性充血和视网膜氧水平的可能治疗方法，以及糖尿病大脑中发生的功能性充血变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Visual Neuroscience 医学-神经科学

CiteScore

2.20

自引率

5.30%

发文量

审稿时长

>12 weeks

期刊介绍： Visual Neuroscience is an international journal devoted to the publication of experimental and theoretical research on biological mechanisms of vision. A major goal of publication is to bring together in one journal a broad range of studies that reflect the diversity and originality of all aspects of neuroscience research relating to the visual system. Contributions may address molecular, cellular or systems-level processes in either vertebrate or invertebrate species. The journal publishes work based on a wide range of technical approaches, including molecular genetics, anatomy, physiology, psychophysics and imaging, and utilizing comparative, developmental, theoretical or computational approaches to understand the biology of vision and visuo-motor control. The journal also publishes research seeking to understand disorders of the visual system and strategies for restoring vision. Studies based exclusively on clinical, psychophysiological or behavioral data are welcomed, provided that they address questions concerning neural mechanisms of vision or provide insight into visual dysfunction.