The current state of PEEK implant osseointegration and future perspectives: a systematic review.

IF 3.2 3区医学 Q3 CELL & TISSUE ENGINEERING

European cells & materials Pub Date : 2020-07-15 DOI:10.22203/eCM.v040a01

N AlOtaibi, K Naudi, D Conway, A Ayoub

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引用次数: 18

Abstract

Polyetheretherketone (PEEK) has been considered as an alternative to replace surgical metal implants. Several medical applications, including dental and orthopaedic implants, need confirmed osseointegration before functional loading. The present study aims at providing a comprehensive systematic review of the evidence on PEEK implants' osseointegration. A systematic search was conducted using Cochrane library, MEDLINE (PubMed), Ovid MEDLINE, Web of Science and EMBASE databases. Publications were identified in accordance with specific inclusion and exclusion criteria. Eligibility screening, data extraction and quality assessment were performed. The review protocol was registered in PROSPERO (CRD42018116061). A total of 55 articles were reviewed and 29 of the most relevant that met the inclusion criteria were selected. Heterogeneity was identified among the included studies. Several approaches have been applied to enhance PEEK osseointegration, with most in vivo studies conducted on small-scale animal models but no study evaluating the osseointegration of PEEK under cyclic loading. However, PEEK modifications are demonstrated to enhance osseointegration preclinically. Collectively, the present review shows a shortage of evidence, including a lack of comprehensive assessment of osseointegration, the need for large-animal-model tests, the need to assess the effect of loading on the implants and the lack of randomised controlled clinical trials.

查看原文本刊更多论文

PEEK种植体骨整合的现状及未来展望:系统综述。

聚醚醚酮(PEEK)被认为是外科金属植入物的替代品。一些医疗应用，包括牙科和骨科植入物，在功能加载之前需要确认骨整合。本研究旨在对PEEK种植体骨整合的证据进行全面系统的综述。系统检索Cochrane图书馆、MEDLINE (PubMed)、Ovid MEDLINE、Web of Science和EMBASE数据库。根据具体的纳入和排除标准确定出版物。进行资格筛选、数据提取和质量评估。该审查方案已在PROSPERO注册(CRD42018116061)。共审查了55篇文章，选择了符合纳入标准的29篇最相关的文章。在纳入的研究中发现了异质性。已有几种方法被应用于增强PEEK的骨整合，大多数的体内研究都是在小尺度动物模型上进行的，但没有研究评估PEEK在循环载荷下的骨整合。然而，PEEK修饰被证明可以增强临床前的骨整合。总的来说，目前的综述显示缺乏证据，包括缺乏对骨整合的全面评估，需要进行大型动物模型试验，需要评估载荷对种植体的影响，以及缺乏随机对照临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European cells & materials 生物-材料科学：生物材料

CiteScore

6.00

自引率

6.50%

发文量

审稿时长

1.5 months

期刊介绍： eCM provides an interdisciplinary forum for publication of preclinical research in the musculoskeletal field (Trauma, Maxillofacial (including dental), Spine and Orthopaedics). The clinical relevance of the work must be briefly mentioned within the abstract, and in more detail in the paper. Poor abstracts which do not concisely cover the paper contents will not be sent for review. Incremental steps in research will not be entertained by eCM journal.Cross-disciplinary papers that go across our scope areas are welcomed.