Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.

IF 3.4 Q1 Agricultural and Biological Sciences
Shengchao Ma, Hehe Liu, Wenqiang Sun, Ahsan Mustafa, Yang Xi, Fajun Pu, Yanying Li, Chunchun Han, Lili Bai, He Hua
{"title":"Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.","authors":"Shengchao Ma,&nbsp;Hehe Liu,&nbsp;Wenqiang Sun,&nbsp;Ahsan Mustafa,&nbsp;Yang Xi,&nbsp;Fajun Pu,&nbsp;Yanying Li,&nbsp;Chunchun Han,&nbsp;Lili Bai,&nbsp;He Hua","doi":"10.1186/s12862-020-01654-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds.</p><p><strong>Results: </strong>We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution.</p><p><strong>Conclusions: </strong>We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.</p>","PeriodicalId":9111,"journal":{"name":"BMC Evolutionary Biology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12862-020-01654-z","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Evolutionary Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12862-020-01654-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 2

Abstract

Background: ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds.

Results: We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution.

Conclusions: We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.

Abstract Image

Abstract Image

Abstract Image

鸟类atp结合盒亚家族G成员2基因亚家族及其类似物的分子进化。
背景:atp结合盒(ABC)转运体参与多种内源性或外源性物质的主动运输。在鸟类中已鉴定出两个ABCG2基因亚家族成员。对ABCG2和ABCG2样基因进行详细的比较研究,有助于我们在分子水平上了解它们的进化史,并为研究ABCG2和ABCG2样基因在鸟类中的具体功能提供理论参考。结果:首次在41只鸟类基因组中鉴定出77个ABCG2/ABCG2样基因序列。进一步分析表明,ABCG2和ABCG2样基因的核酸和氨基酸序列在鸟类中高度保守,具有高度同源性。然而,ABCG2和ABCG2样氨基酸序列的n端结构存在显著差异。选择压力分析表明,ABCG2和ABCG2样基因在鸟类进化过程中受到纯化选择的影响。结论:我们认为鸟类祖先的4号染色体上存在多个ABCG2基因亚家族成员。在漫长的进化过程中,鸟类的4号染色体上只保留了ABCG2基因。6号染色体上的abcg2样基因可能起源于染色体复制或融合。ABCG2蛋白N端与ABCG2样蛋白N端结构上的差异可能导致相应基因功能上的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMC Evolutionary Biology
BMC Evolutionary Biology 生物-进化生物学
CiteScore
5.80
自引率
0.00%
发文量
0
审稿时长
6 months
期刊介绍: BMC Evolutionary Biology is an open access, peer-reviewed journal that considers articles on all aspects of molecular and non-molecular evolution of all organisms, as well as phylogenetics and palaeontology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信