A Wolbachia infection model with free boundary.

Abstract

Scientists have been seeking ways to use Wolbachia to eliminate the mosquitoes that spread human diseases. Could Wolbachia be the determining factor in controlling the mosquito-borne infectious diseases? To answer this question mathematically, we develop a reaction-diffusion model with free boundary in a one-dimensional environment. We divide the female mosquito population into two groups: one is the uninfected mosquito population that grows in the whole region while the other is the mosquito population infected with Wolbachia that occupies a finite small region. The mosquito population infected with Wolbachia invades the environment with a spreading front governed by a free boundary satisfying the well-known one-phase Stefan condition. For the resulting free boundary problem, we establish criteria under which spreading and vanishing occur. Our results provide useful insights on designing a feasible mosquito releasing strategy that infects the whole mosquito population with Wolbachia and eradicates the mosquito-borne diseases eventually.