Jennifer Johnson, Andrei Malinovschi, Jonas Lidholm, Carl Johan Petersson, Lennart Nordvall, Christer Janson, Kjell Alving, Magnus P Borres
{"title":"Sensitization to storage proteins in peanut and hazelnut is associated with higher levels of inflammatory markers in asthma.","authors":"Jennifer Johnson, Andrei Malinovschi, Jonas Lidholm, Carl Johan Petersson, Lennart Nordvall, Christer Janson, Kjell Alving, Magnus P Borres","doi":"10.1186/s12948-020-00126-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Sensitization to peanuts and hazelnuts is common among young asthmatics and can be primary or a result of cross-reactivity. Sensitization as a result of cross-reactivity to birch pollen is typically associated to tolerance or mild and local symptoms upon intake of peanut or hazelnut.</p><p><strong>Aim: </strong>The aim of this study was to investigate relationships between IgE antibody responses against peanut and hazelnut components, airway and systemic inflammation markers, lung function parameters and reported food hypersensitivity in a cohort of asthmatic children and young adults.</p><p><strong>Methods: </strong>A population of 408 asthmatic individuals aged 10-35 years were investigated. Information on hypersensitivity symptoms upon intake of peanut or hazelnut were recorded in a standardized questionnaire. Fraction of exhaled nitric oxide (FeNO), blood eosinophil count (B-Eos), spirometry, methacholine challenge outcome and IgE antibodies to peanut and hazelnut allergens were measured by standard clinical and laboratory methods.</p><p><strong>Results: </strong>Subjects sensitized to any of the peanut (Ara h 1, 2 or 3) or hazelnut (Cor a 9 or 14) storage proteins were significantly younger (17.6 vs 21.2 years), had higher levels of FeNO (23.2 vs 16.7 ppb) and B-Eos (340 vs 170 cells/mcl) than those displaying only pollen-related cross-reactive sensitization. Levels of FeNO correlated with levels of IgE to storage proteins in children, but not in adults. Levels of B-Eos correlated with levels of IgE to all allergen components investigated in children, but only to levels of IgE to storage proteins in adults. Anaphylaxis and skin reactions upon intake of peanuts or hazelnuts were more often reported among subjects sensitized to the respective storage proteins than among those with only pollen-related cross-reactive sensitization. As compared to peanut, hazelnut was more often reported to cause gastrointestinal symptoms and less often oral cavity symptoms.</p><p><strong>Conclusions: </strong>Sensitization to peanut and hazelnut storage proteins was associated with higher levels of inflammation markers and food hypersensitivity symptoms in this population of subjects with asthma.</p>","PeriodicalId":38753,"journal":{"name":"Clinical and Molecular Allergy","volume":"18 ","pages":"11"},"PeriodicalIF":0.0000,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12948-020-00126-5","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Molecular Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12948-020-00126-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 7
Abstract
Background: Sensitization to peanuts and hazelnuts is common among young asthmatics and can be primary or a result of cross-reactivity. Sensitization as a result of cross-reactivity to birch pollen is typically associated to tolerance or mild and local symptoms upon intake of peanut or hazelnut.
Aim: The aim of this study was to investigate relationships between IgE antibody responses against peanut and hazelnut components, airway and systemic inflammation markers, lung function parameters and reported food hypersensitivity in a cohort of asthmatic children and young adults.
Methods: A population of 408 asthmatic individuals aged 10-35 years were investigated. Information on hypersensitivity symptoms upon intake of peanut or hazelnut were recorded in a standardized questionnaire. Fraction of exhaled nitric oxide (FeNO), blood eosinophil count (B-Eos), spirometry, methacholine challenge outcome and IgE antibodies to peanut and hazelnut allergens were measured by standard clinical and laboratory methods.
Results: Subjects sensitized to any of the peanut (Ara h 1, 2 or 3) or hazelnut (Cor a 9 or 14) storage proteins were significantly younger (17.6 vs 21.2 years), had higher levels of FeNO (23.2 vs 16.7 ppb) and B-Eos (340 vs 170 cells/mcl) than those displaying only pollen-related cross-reactive sensitization. Levels of FeNO correlated with levels of IgE to storage proteins in children, but not in adults. Levels of B-Eos correlated with levels of IgE to all allergen components investigated in children, but only to levels of IgE to storage proteins in adults. Anaphylaxis and skin reactions upon intake of peanuts or hazelnuts were more often reported among subjects sensitized to the respective storage proteins than among those with only pollen-related cross-reactive sensitization. As compared to peanut, hazelnut was more often reported to cause gastrointestinal symptoms and less often oral cavity symptoms.
Conclusions: Sensitization to peanut and hazelnut storage proteins was associated with higher levels of inflammation markers and food hypersensitivity symptoms in this population of subjects with asthma.
背景:花生和榛子致敏在年轻哮喘患者中很常见，可能是原发的，也可能是交叉反应的结果。对桦树花粉的交叉反应导致的致敏通常与摄入花生或榛子后的耐受性或轻度和局部症状有关。目的:本研究的目的是研究哮喘儿童和青少年队列中针对花生和榛子成分、气道和全身炎症标志物、肺功能参数和报告的食物过敏反应的IgE抗体反应之间的关系。方法:对408例10 ~ 35岁的哮喘患者进行调查。摄入花生或榛子后过敏症状的信息记录在标准化问卷中。采用标准临床和实验室方法测定呼出一氧化氮(FeNO)、血嗜酸性粒细胞计数(B-Eos)、肺活量测定、甲胆碱激发结果和花生和榛子过敏原的IgE抗体。结果:对花生(Ara h 1、2或3)或榛子(Cor a 9或14)储存蛋白致敏的受试者明显更年轻(17.6岁vs 21.2岁)，FeNO (23.2 vs 16.7 ppb)和B-Eos (340 vs 170细胞/mcl)水平高于仅显示花粉相关交叉反应致敏的受试者。在儿童中，FeNO水平与IgE储存蛋白水平相关，但在成人中没有。B-Eos水平与儿童中所有过敏原成分的IgE水平相关，但仅与成人中储存蛋白的IgE水平相关。摄入花生或榛子后的过敏反应和皮肤反应在对各自的储存蛋白敏感的受试者中比在仅与花粉相关的交叉反应致敏的受试者中更常见。与花生相比，榛子更常引起胃肠道症状，而较少引起口腔症状。结论:在哮喘患者中，花生和榛子贮藏蛋白致敏与较高水平的炎症标志物和食物过敏症状相关。
期刊介绍：
Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
