Double the Fun, Double the Trouble: Paralogs and Homologs Functioning in the Endoplasmic Reticulum.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Emma J Fenech, Shifra Ben-Dor, Maya Schuldiner
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引用次数: 9

Abstract

The evolution of eukaryotic genomes has been propelled by a series of gene duplication events, leading to an expansion in new functions and pathways. While duplicate genes may retain some functional redundancy, it is clear that to survive selection they cannot simply serve as a backup but rather must acquire distinct functions required for cellular processes to work accurately and efficiently. Understanding these differences and characterizing gene-specific functions is complex. Here we explore different gene pairs and families within the context of the endoplasmic reticulum (ER), the main cellular hub of lipid biosynthesis and the entry site for the secretory pathway. Focusing on each of the ER functions, we highlight specificities of related proteins and the capabilities conferred to cells through their conservation. More generally, these examples suggest why related genes have been maintained by evolutionary forces and provide a conceptual framework to experimentally determine why they have survived selection.

乐趣加倍,麻烦加倍:内质网中的类似物和同源物功能。
真核生物基因组的进化是由一系列基因复制事件推动的,导致了新的功能和途径的扩展。虽然重复基因可能保留一些功能冗余,但很明显,为了在选择中生存下来,它们不能简单地作为备份,而是必须获得细胞过程准确有效地工作所需的独特功能。理解这些差异和描述基因特异性功能是复杂的。在这里,我们探讨了内质网(ER)背景下的不同基因对和家族,内质网是脂质生物合成的主要细胞中心和分泌途径的进入位点。关注内质网的每一个功能,我们强调了相关蛋白的特异性和通过它们的保护赋予细胞的能力。更一般地说,这些例子说明了为什么相关基因通过进化力量得以维持,并提供了一个概念性框架来实验确定它们为什么在选择中幸存下来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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