Biosynthesis and Export of Bacterial Glycolipids.

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Christopher A Caffalette, Jeremi Kuklewicz, Nicholas Spellmon, Jochen Zimmer
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引用次数: 18

Abstract

Complex carbohydrates are essential for many biological processes, from protein quality control to cell recognition, energy storage, and cell wall formation. Many of these processes are performed in topologically extracellular compartments or on the cell surface; hence, diverse secretion systems evolved to transport the hydrophilic molecules to their sites of action. Polyprenyl lipids serve as ubiquitous anchors and facilitators of these transport processes. Here, we summarize and compare bacterial biosynthesis pathways relying on the recognition and transport of lipid-linked complex carbohydrates. In particular, we compare transporters implicated in O antigen and capsular polysaccharide biosyntheses with those facilitating teichoic acid and N-linked glycan transport. Further, we discuss recent insights into the generation, recognition, and recycling of polyprenyl lipids.
细菌糖脂的生物合成和输出。
复合碳水化合物是许多生物过程所必需的,从蛋白质质量控制到细胞识别、能量储存和细胞壁形成。许多这些过程在拓扑结构上的细胞外区室或细胞表面进行;因此,不同的分泌系统进化来运输亲水分子到它们的作用部位。聚戊烯基脂作为无处不在的锚和促进这些运输过程。在这里,我们总结并比较了依赖于脂质连接的复合碳水化合物的识别和运输的细菌生物合成途径。特别地,我们比较了涉及O抗原和荚膜多糖生物合成的转运蛋白与那些促进磷壁酸和n链聚糖运输的转运蛋白。此外,我们讨论了最近对聚戊烯基脂的产生,识别和回收的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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