The Role of Highly Active Antiretroviral Therapy (HAART) on Interleukin 17A (IL-17A) in Normotensive and Preeclamptic Black South African Women.

Q2 Medicine

Infectious Diseases in Obstetrics and Gynecology Pub Date : 2020-05-30 eCollection Date: 2020-01-01 DOI:10.1155/2020/3417632

Wendy N Phoswa, Thajasvarie Naicker, Veron Ramsuran, Jagidesa Moodley

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引用次数: 4

Abstract

Introduction: Interleukin 17A has been implicated in the pathophysiology of both human immune deficiency virus and preeclampsia. This study evaluated serum levels of IL-17A based on pregnancy type, gestational age, HIV status, and duration of HAART. Material and Methods. A sample size of 250 was analysed: normotensives (n = 150; N) and preeclamptics (n = 100; PE). Normotensives were further stratified into HIV negative (n = 90), HAART-acute (n = 30), and HAART-chronic (n = 30). The PE group was divided into early onset (n = 50; EOPE) and late onset (n = 50; LOPE). The EOPE and LOPE groups were subdivided into HIV negative (n = 30), HAART-acute (n = 10), and HAART-chronic (n = 10). Analysis of IL-17A was performed using a multiple Bio-Plex immunoassay method.

Results: Pregnancy type: the levels of IL-17A were increased in PE compared to N (P = 0.0014). Gestational age: the levels of IL-17A were increased in EOPE compared to N group (P = 0.0113). A significant increase in the levels of IL-17A in LOPE compared to N was observed (P = 0.0063). HIV status: the levels of IL-17A were increased in PE compared to N (P = 0.0114) and in EOPE compared to N groups (P = 0.0071). HAART duration: the concentration of IL-17A was increased in HAART-chronic PE compared to N groups (P = 0.0062). There was also an increase in the levels of IL-17A in EOPE compared to N (P = 0.0029).

Conclusion: The study demonstrates that IL-17A is involved in the pathophysiology of PE and that in the presence of HIV infection, chronic HAART administration predisposes women to the development of EOPE.

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高活性抗逆转录病毒治疗(HAART)对正常血压和子痫前期南非黑人妇女白细胞介素17A (IL-17A)的作用

导论:白细胞介素17A参与了人类免疫缺陷病毒和子痫前期的病理生理。本研究基于妊娠类型、胎龄、HIV状态和HAART持续时间评估血清IL-17A水平。材料和方法。分析了250个样本量:正常血压(n = 150;N)和子痫前期(N = 100;PE)。正常血压者进一步分为HIV阴性(n = 90)、急性haart治疗(n = 30)和慢性haart治疗(n = 30)。PE组分为早发型组(n = 50;EOPE)和晚发(n = 50;洛佩)。EOPE组和LOPE组又分为HIV阴性组(n = 30)、急性haart组(n = 10)和慢性haart组(n = 10)。采用多重Bio-Plex免疫分析法对IL-17A进行分析。结果:妊娠型:PE组IL-17A水平较N组升高(P = 0.0014)。胎龄:与N组相比，EOPE组IL-17A水平升高(P = 0.0113)。与N组相比，LOPE组IL-17A水平显著升高(P = 0.0063)。HIV状态:与N组相比，PE组IL-17A水平升高(P = 0.0114)， EOPE组与N组相比IL-17A水平升高(P = 0.0071)。HAART持续时间:与N组相比，HAART-慢性PE组IL-17A浓度升高(P = 0.0062)。与N组相比，EOPE组IL-17A水平也有所增加(P = 0.0029)。结论:本研究表明IL-17A参与PE的病理生理，在HIV感染的情况下，慢性HAART治疗使女性易患EOPE。

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来源期刊

Infectious Diseases in Obstetrics and Gynecology Medicine-Obstetrics and Gynecology

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Infectious Diseases in Obstetrics and Gynecology aims to disseminate new and important information to clinicians and other health care providers, scientists, and researchers involved in the study or treatment of infectious diseases, especially those affecting the female patient. Its ultimate aim is to advance knowledge and encourage research, thereby improving the prevention or diagnosis and treatment of patients affected by such diseases.