Predictive and Prognostic Value of Ascitic Fluid Mannose Binding Lectin in Patients with Spontaneous Bacterial Peritonitis.

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871523019666200617132513

Amal A Mohamed, Mohamed Abdelhamid, Naglaa El-Toukhy, Ahmed Sabry, Rania A Khattab, Dalia Ali El-Damasy, Abeer Ahmed, Mahmoud Elkadeem, Sherief Abd-Elsalam

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引用次数: 2

Abstract

Background: Spontaneous bacterial peritonitis is a common bacterial infection of ascitic fluid, mainly in ascites due to liver cirrhosis. Mannose-binding lectin (MBL) can activate phagocytosis and the complement system. Spontaneous bacterial peritonitis was detected to be higher in MBL deficiency. This study aimed to assess ascitic fluid MBL in liver cirrhosis and spontaneous bacterial peritonitis.

Methods: Ninety patients with cirrhotic ascites were included. Forty five of them had SBP. Child- Pugh score, Model for End Stage Liver Disease (MELD) and its update (uMELD) scores were used to assess the severity of liver cirrhosis. Ascitic fluid samples were obtained for differentiation of leucocytic count, estimation of albumin, protein, glucose, and serum-ascitic albumin gradient. Ascitic fluid levels of MBL were measured for all patients. SBP was documented if polymorphonuclear leucocytic count ≥250/mm in ascitic fluid.

Results: Ascitic fluid MBL level was significantly lower in patients with SBP. MBL had a significant negative correlation with ascitic total leukocytic count (TLC), also with serum creatinine, bilirubin, PT, INR and MELD score among SBP patients. However, it had a significant positive correlation with ascitic protein and with platelets. According to multivariate analysis, fever, TLC, platelets, creatinine, MBL, glucose and polymorphs were independent predictors for SBP development.

Conclusion: Ascitic fluid MBL could be a good predictive and prognostic marker in patients with cirrhosis and spontaneous bacterial peritonitis.

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腹水甘露糖结合凝集素对自发性细菌性腹膜炎的预测和预后价值。

背景:自发性细菌性腹膜炎是一种常见的腹水细菌感染，主要发生在肝硬化引起的腹水。甘露糖结合凝集素(MBL)具有激活吞噬和补体系统的作用。自发性细菌性腹膜炎在MBL缺乏组中发生率较高。本研究旨在评估腹水MBL在肝硬化和自发性细菌性腹膜炎中的作用。方法:90例肝硬化腹水患者。其中45人有收缩压。Child- Pugh评分、终末期肝病模型(MELD)及其更新(uMELD)评分用于评估肝硬化的严重程度。获得腹水样本用于白细胞计数的分化，白蛋白，蛋白，葡萄糖和血清-腹水白蛋白梯度的估计。测量所有患者MBL的腹水水平。如果腹水中多形核白细胞计数≥250/mm，则记录收缩压。结果:收缩压患者腹水MBL水平明显降低。SBP患者MBL与腹水总白细胞计数(TLC)、血清肌酐、胆红素、PT、INR、MELD评分均呈显著负相关。但与腹水蛋白、血小板呈显著正相关。根据多因素分析，发热、TLC、血小板、肌酐、MBL、葡萄糖和多态性是SBP发展的独立预测因子。结论:腹水MBL可作为肝硬化合并自发性细菌性腹膜炎的良好预测和预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.