Abed Pablo, Autumn R. Breaud, William Clarke
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引用次数: 1
Abstract
Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is an important analytical method for quantification of busulfan in plasma in order to optimize the dose. © 2020 Wiley Periodicals LLC.
Basic Protocol: Analysis of busulfan by liquid chromatography/mass spectrometry
液相色谱-串联质谱法(LC-MS/MS)分析血浆中布苏凡
骨髓移植用于治疗特定类型的癌症，如淋巴瘤、白血病和多发性骨髓瘤。在准备阶段适当剂量的丁硫丹对同种异体移植的成功至关重要;如果血药浓度过高，可发生显著的肝毒性，如果血药浓度过低，则可发展为移植物抗宿主病(GVHD)。血液中的Busulfan监测使医院有机会为患者提供个性化药物并改善患者的整体预后。液相色谱-串联质谱法(LC-MS/MS)是一种重要的定量分析方法，用于优化血浆中磺胺的剂量。©2020 Wiley Periodicals llc .基本方案:用液相色谱/质谱法分析丁硫丹
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