Association of the NEGR1 rs2815752 with obesity and related traits in Pakistani females.

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Upsala journal of medical sciences Pub Date : 2020-08-01 Epub Date: 2020-05-18 DOI:10.1080/03009734.2020.1756996
Sobia Rana, Maha Mobin
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引用次数: 0

Abstract

Introduction: The variant NEGR1 rs2815752 has recently been linked with obesity in Caucasians. However, a very limited number of studies have examined the association of the NEGR1 rs2815752 with overweight/obesity in non-Caucasians with no such study ever performed in Pakistani population. Therefore, the present study was undertaken to seek the association of the rs2815752 with overweight, obesity, and related traits in Pakistanis.Subjects and methods: The study involved 112 overweight/control pairs (total 224) and 194 obese/control pairs (total 388). Anthropometric parameters were measured by employing standard procedures. Metabolic parameters were determined by biochemical assays. Behavioral information was collected through a questionnaire. The rs2815752 was genotyped via TaqMan allelic discrimination assay. Regression analyses were employed to analyze the data in SPSS software.Results: The study revealed significant gender-specific association of the rs2815752 with obesity (OR 3.03; CI 1.19-7.72, p = 0.020) and some obesity-related anomalous anthropometric traits (weight, BMI, waist circumference, hip circumference, and abdominal and supra-iliac skinfold thicknesses) in females according to dominant model (h = 0.023). However, no association of the rs2815752 with obesity-related behavioral and metabolic parameters was observed.Conclusion: The NEGR1 rs2815752 may be associated with obese phenotype and some of the related anthropometric traits in Pakistani females.

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NEGR1 rs2815752与巴基斯坦女性肥胖及相关性状的关系
最近发现变异NEGR1 rs2815752与高加索人的肥胖有关。然而,研究NEGR1 rs2815752与非白种人超重/肥胖的关系的研究数量非常有限,没有在巴基斯坦人群中进行过此类研究。因此,本研究旨在寻找rs2815752基因与巴基斯坦人超重、肥胖及相关性状的关系。研究对象和方法:研究涉及112对超重/对照(共224对)和194对肥胖/对照(共388对)。采用标准程序测量人体测量参数。通过生化试验测定代谢参数。行为信息通过问卷收集。通过TaqMan等位基因鉴别试验对rs2815752进行基因分型。采用SPSS软件对数据进行回归分析。结果:研究显示rs2815752基因与肥胖存在显著的性别特异性关联(OR 3.03;根据优势模型,CI 1.19-7.72, p = 0.020)和一些与肥胖相关的异常人体测量特征(体重、BMI、腰围、臀围、腹部和髂上皮褶厚度)(h = 0.023)。然而,没有观察到rs2815752与肥胖相关的行为和代谢参数的关联。结论:NEGR1 rs2815752基因可能与巴基斯坦女性肥胖表型及相关人体特征有关。
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来源期刊
Upsala journal of medical sciences
Upsala journal of medical sciences 医学-医学:内科
CiteScore
5.60
自引率
0.00%
发文量
31
审稿时长
6-12 weeks
期刊介绍: Upsala Journal of Medical Sciences is published for the Upsala Medical Society. It has been published since 1865 and is one of the oldest medical journals in Sweden. The journal publishes clinical and experimental original works in the medical field. Although focusing on regional issues, the journal always welcomes contributions from outside Sweden. Specially extended issues are published occasionally, dealing with special topics, congress proceedings and academic dissertations.
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