PPARs and the Development of Type 1 Diabetes.

IF 3.5 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

PPAR Research Pub Date : 2020-01-09 eCollection Date: 2020-01-01 DOI:10.1155/2020/6198628

Laurits J Holm, Mia Øgaard Mønsted, Martin Haupt-Jorgensen, Karsten Buschard

引用次数: 18

Abstract

Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.

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ppar与1型糖尿病的发展。

过氧化物酶体增殖物激活受体(PPARs)是一类转录因子，在糖脂代谢中起关键作用。ppar在许多细胞类型中表达，包括胰腺β细胞和免疫细胞，它们分别调节胰岛素分泌和T细胞分化。此外，各种PPAR激动剂可以预防1型糖尿病非肥胖糖尿病(NOD)小鼠模型中的糖尿病。因此，ppar在1型糖尿病(T1D)中引起了人们的兴趣，因为它们代表了一种针对胰腺和免疫系统的新方法。在这篇综述中，我们研究了ppar在免疫反应和β细胞生物学中的作用，以及它们作为治疗T1D的潜在靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.20

自引率

3.40%

发文量

审稿时长

12 months

期刊介绍： PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.