Association of 25-hydroxy vitamin D with asthma and its severity in children: a case-control study.

Q2 Medicine

Clinical and Molecular Allergy Pub Date : 2020-05-04 eCollection Date: 2020-01-01 DOI:10.1186/s12948-020-00122-9

Alireza Sharif, Hamed Haddad Kashani, Mohammad Reza Sharif

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引用次数: 4

Abstract

Background: Universally, asthma has high prevalence rates and this has led numerous studies done into its causes. Despite extensive study on asthma the association between 25-Hydroxy Vitamin D (25(OH) vit. D) and asthma remains uncertain. In this study, the associations of 25(OH) vit. D levels with asthma and with the severity of asthma were evaluated.

Methods: This was a case-control study performed in 2015 in the city of Isfahan. In this study 520 children were studied. Children with asthma were classified as cases and children who were referred for reasons other than respiratory problems and asthma were considered as controls. Serum 25 (OH) vit. D levels were then examined and compared between the two groups. Differences among groups were stated to be statistically significant when P-values < 0.05.

Results: There were 260 asthmatic children and 260 controls in the present study. The mean 25 (OH) vit. D levels in the case group was 25.5 ± 16.62 and 16.76 ± 31.40 the control group and this difference was statistically significant (P < 0.05). 25(OH) vit. D levels were found to be 28.05 ± 16.98 in non-severe asthma and 21.41 ± 15.20 in severe asthma. Consequently 25(OH) vit. D level had inverse relationship with asthma severity (P = 0.002).

Conclusions: As the results of this study showed, the lower level of 25(OH) vit. D correlated with the higher severity of asthma manifestations. Therefore, it is recommended that 25(OH) vit. D levels get routinely checked especially in severe asthma cases and if the deficiency presents, appropriate therapeutic measures be used to reduce the asthma severity.

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25-羟基维生素D与儿童哮喘及其严重程度的关系:一项病例对照研究

背景:在全球范围内，哮喘的患病率很高，这导致了对其病因的大量研究。尽管对哮喘进行了广泛的研究，但25-羟基维生素D (25(OH)维生素)与哮喘之间的关系。D)和哮喘仍然不确定。在本研究中，25(OH) vit的相关性。评估哮喘患者和哮喘严重程度患者的D水平。方法:本研究为2015年在伊斯法罕市开展的病例对照研究。这项研究调查了520名儿童。患有哮喘的儿童被归类为病例，而因呼吸问题和哮喘以外的原因转诊的儿童被视为对照。血清25 (OH) vit。然后检查并比较两组之间的D水平。结果:本研究哮喘患儿260例，对照组260例。平均25 (OH) vit。病例组D水平为25.5±16.62，对照组为16.76±31.40，差异有统计学意义(P)结论:本研究结果显示，25(OH) vit水平较低。D与哮喘表现的严重程度较高相关。建议使用25(OH) vit。定期检查D水平，特别是在严重哮喘病例中，如果出现D缺乏，应采用适当的治疗措施来降低哮喘的严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.