Safety and Efficacy of Oral Melatonin When Combined with Thoracic Epidural Analgesia in Patients with Bilateral Multiple Fracture Ribs.

IF 1.5 Q3 ANESTHESIOLOGY
Local and Regional Anesthesia Pub Date : 2020-04-14 eCollection Date: 2020-01-01 DOI:10.2147/LRA.S244510
Ahmed M Fetouh Abdelrahman, Amany Faheem Abdel Salam Omara, Alaa Ali M Elzohry
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引用次数: 0

Abstract

Background: The purpose of this study is to evaluate the safety and efficacy of oral melatonin administered with thoracic epidural analgesia in patients with multiple bilateral fractured ribs.

Patients and methods: A prospective, double-blind randomized control study was carried out on 80 patients of either sex, American Society of Anesthesiologists (ASA) Grade I and II, aged above 18 years, presenting with multiple bilateral fractured ribs. They were randomly divided into two groups, 40 patients each. Placebo group patients received oral placebo tablets and melatonin group (TEA and melatonin) patients received oral melatonin tablets (5 mg), about 1 hour before epidural infusion of local anesthetics and then every 12 hours till the cessation of bupivacaine infusion.

Results: Melatonin administration was associated with a significant decrease in total morphine analgesia consumption, from 31.8 ± 1.41 mg in the TE group to 13.03 ± 0.85 mg in the melatonin group (P < 0.001), with a significant decrease (P < 0.001) in the mean infusion rate of bupivacaine required for controlling the pain, from 0.17 ± 0.014 mL/kg/hour in the TE group to 0.12 ± 0.001 mL/kg/hour in the melatonin group. The duration of bupivacaine infusion in the melatonin group was also significantly shorter than in the TE group (96.48 ± 1.87 and 100.05 ± 3.39 hours, resp., P < 0.001).

Conclusion: We conclude that premedication of patients with 5 mg melatonin is associated with significant prolongation of thoracic epidural analgesic effects compared to placebo.

Registration: This clinical study was registered at Pan African Clinical Trial Registry with no. "PACTR 201711002741378" on 02-11-2017.

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口服褪黑素与胸硬膜外镇痛联合应用于双侧多发性肋骨骨折患者的安全性和有效性
研究背景本研究的目的是评估口服褪黑素并配合胸硬膜外镇痛对双侧多发性肋骨骨折患者的安全性和有效性:这项前瞻性双盲随机对照研究的对象是80名年龄在18岁以上、双侧多根肋骨骨折的美国麻醉医师协会(ASA)Ⅰ级和Ⅱ级男女患者。他们被随机分为两组,每组 40 人。安慰剂组患者口服安慰剂片剂,褪黑素组(三乙醇胺和褪黑素)患者在硬膜外注射局麻药前约 1 小时口服褪黑素片剂(5 毫克),然后每 12 小时注射一次,直至停止注射布比卡因:使用褪黑素后,吗啡镇痛剂的总消耗量显著减少,从 TE 组的 31.8 ± 1.41 毫克减少到褪黑素组的 13.03 ± 0.85 毫克(P 结论:褪黑素能显著减少吗啡镇痛剂的总消耗量:我们得出结论:与安慰剂相比,给患者使用5毫克褪黑素预处理可显著延长胸硬膜外镇痛效果:本临床研究已在泛非临床试验注册中心注册,注册号为 "PACTR 2017110027"。"PACTR 201711002741378"。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.30
自引率
0.00%
发文量
12
审稿时长
16 weeks
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