Through veiled mirrors: Fish fins giving insight into size regulation.

Q1 Biochemistry, Genetics and Molecular Biology

Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2021-07-01 Epub Date: 2020-04-23 DOI:10.1002/wdev.381

Matthew P Harris, Jacob M Daane, Jennifer Lanni

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引用次数: 11

Abstract

Faithful establishment and maintenance of proportion is seen across biological systems and provides a glimpse at fundamental rules of scaling that underlie development and evolution. Dysregulation of proportion is observed in a range of human diseases and growth disorders, indicating that proper scaling is an essential component of normal anatomy and physiology. However, when viewed through an evolutionary lens, shifts in the regulation of relative proportion are one of the most striking sources of morphological diversity among organisms. To date, the mechanisms via which relative proportion is specified and maintained remain unclear. Through the application of powerful experimental, genetic and molecular approaches, the teleost fin has provided an effective model to investigate the regulation of scaling, size, and relative growth in vertebrate organisms. This article is categorized under: Establishment of Spatial and Temporal Patterns > Regulation of Size, Proportion, and Timing Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Comparative Development and Evolution > Regulation of Organ Diversity.

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透过蒙着面纱的镜子:鱼鳍提供了对大小调节的洞察。

在整个生物系统中都可以看到比例的忠实建立和维持，并提供了对发展和进化基础的基本比例规则的一瞥。在一系列人类疾病和生长障碍中观察到比例失调，表明适当的缩放是正常解剖和生理的重要组成部分。然而，当从进化的角度来看，相对比例调节的变化是生物形态多样性最显著的来源之一。迄今为止，确定和维持相对比例的机制尚不清楚。硬骨鱼鳍通过强大的实验、遗传和分子方法的应用，为研究脊椎动物的鳞片、大小和相对生长的调节提供了有效的模型。本文分类为:时空格局的建立>成体干细胞、组织更新与再生的大小、比例和时间调控>再生比较发育和进化>器官多样性调控。

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Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.