Impact of maternal and neonatal factors on umbilical cord CD34⁺ cells.

Q1 Biochemistry, Genetics and Molecular Biology

Stem cell investigation Pub Date : 2020-03-31 eCollection Date: 2020-01-01 DOI:10.21037/sci.2020.03.01

Mohamed A Rowisha, Mohamed R El-Shanshory, Eslam E El-Hawary, Amira Youssef Ahmed, Shafeq Ryad Mustafa Altoraky

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引用次数: 3

Abstract

Background: The achievement of optimal number of CD34⁺ umbilical cord stem cells is essential for successful umbilical cord stem cell transplantation. So the aim of this study was to assess the potential effect of both maternal and neonatal factors on the umbilical cord blood CD34⁺ cell count.

Methods: The study was done on umbilical cord blood samples obtained from 20 mothers during labor. Their ages ranged from 22 to 34 years and were subjected to history taking, physical examination of the baby and assessment of the CD34⁺ cells count in umbilical cord blood.

Results: Number of previous live births and weight of the baby had a significant effect on CD34⁺ cells count while the sex of the baby, delivery route, maternal age and gestation period had no significant effect on CD34⁺ cells count.

Conclusions: Umbilical cord blood-derived CD34⁺ cell count is better with good weight and first babies and decreased with subsequent babies.

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母婴因素对脐带CD34+细胞的影响。

背景:获得最佳数量的CD34+脐带干细胞是脐带干细胞移植成功的关键。因此，本研究的目的是评估母体和新生儿因素对脐带血CD34+细胞计数的潜在影响。方法:对20例产妇产程中采集的脐带血进行研究。他们的年龄从22岁到34岁不等，接受了病史记录、婴儿体格检查和脐带血CD34+细胞计数评估。结果:出生次数和体重对CD34+细胞计数有显著影响，而性别、分娩方式、产妇年龄和妊娠期对CD34+细胞计数无显著影响。结论:脐血来源的CD34+细胞计数在新生儿体重正常时较好，在新生儿体重正常时较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

5.80

自引率

0.00%

发文量

期刊介绍： The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.