Retinoic Acid Signaling and Heart Development.

Q1 Biochemistry, Genetics and Molecular Biology

Sub-cellular biochemistry Pub Date : 2020-01-01 DOI:10.1007/978-3-030-42282-0_5

Eliyahu Perl, Joshua S Waxman

引用次数: 3

Abstract

As the first organ to form and function in all vertebrates, the heart is crucial to development. Tightly-regulated levels of retinoic acid (RA) are critical for the establishment of the regulatory networks that drive normal cardiac development. Thus, the heart is an ideal organ to investigate RA signaling, with much work remaining to be done in this area. Herein, we highlight the role of RA signaling in vertebrate heart development and provide an overview of the field's inception, its current state, and in what directions it might progress so that it may yield fruitful insight for therapeutic applications within the domain of regenerative medicine.

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视黄酸信号传导与心脏发育。

作为所有脊椎动物中最早形成和发挥功能的器官，心脏对发育至关重要。视黄酸(RA)的严格调控水平对于驱动心脏正常发育的调控网络的建立至关重要。因此，心脏是研究类风湿性关节炎信号的理想器官，在这一领域还有很多工作要做。在此，我们强调类风酸信号在脊椎动物心脏发育中的作用，并概述该领域的起源、现状以及可能的发展方向，以便为再生医学领域的治疗应用提供富有成效的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sub-cellular biochemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

5.90

自引率

0.00%

发文量

期刊介绍： The book series SUBCELLULAR BIOCHEMISTRY is a renowned and well recognized forum for disseminating advances of emerging topics in Cell Biology and related subjects. All volumes are edited by established scientists and the individual chapters are written by experts on the relevant topic. The individual chapters of each volume are fully citable and indexed in Medline/Pubmed to ensure maximum visibility of the work.