HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome.

Q1 Medicine

Auto-Immunity Highlights Pub Date : 2019-11-15 eCollection Date: 2019-12-01 DOI:10.1186/s13317-019-0122-8

Lucas S Rodrigues, Luiz H da Silva Nali, Cibele O D Leal, Ester C Sabino, Eliana M Lacerda, Caroline C Kingdon, Luis Nacul, Camila M Romano

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引用次数: 11

Abstract

Background: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases.

Methods: Here the expression of Endogenous retroviruses K and W (HERV-K and HERV-W) was determined in blood from moderately and severely affected ME/CFS patients through real time PCR.

Results: HERV-K was overexpressed only in moderately affected individuals but HERV-W showed no difference.

Conclusions: This is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention.

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HERV-K和HERV-W在肌痛性脑脊髓炎/慢性疲劳综合征中的转录活性

背景:慢性疲劳综合征/肌痛性脑脊髓炎(CFS/MS)是一种严重影响生活质量的致残性慢性疾病。CFS/ME的发病机制是多因素的，认为免疫、代谢和环境因素均起作用。有充分的证据表明，来自不同家族的人类内源性逆转录病毒(herv)在自身免疫性和神经系统疾病中的活性增加，使这些元素成为这些疾病的生物标志物甚至触发因素的良好候选物。方法:采用实时荧光定量PCR检测中重度ME/CFS患者血液中内源性逆转录病毒K和W (HERV-K和HERV-W)的表达。结果:HERV-K仅在中度感染个体中过表达，HERV-W无差异。结论:本文首次报道了HERV-K在中度ME/CFS中的差异表达。虽然herv与ME/CFS之间的关系尚未得到证实，但这一现象的观察值得进一步关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Auto-Immunity Highlights IMMUNOLOGY-

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