Isotretinoin.

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2020-01-01 Epub Date: 2019-12-06 DOI:10.1016/bs.podrm.2019.10.005

Nasr Y Khalil, Ibrahim A Darwish, Abdulmohsen A Al-Qahtani

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Abstract

Isotretinoin is chemically named as: (2Z, 4E, 6E, 8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid. It is an orally active retinoic acid derivative for the treatment of severe refractory nodulocystic acne. It acts primarily by reducing sebaceous gland size and sebum production, and as a result alters skin surface lipid composition. Using isotretinoin for 1-2mg/kg/day for 3-4 months produces 60%-95% clearance of inflammatory lesions in patients with acne. Doses as low as 0.1mg/kg/day have also proven successful in the clearance of lesions. Encouraging results have also been seen in small numbers of patients with rosacea, Side effects affecting the mucocutaneous system and raised serum triglyceride levels occur in most patients receiving isotretinoin. Isotretinoin is strictly contraindicated in women of childbearing potential. This profile discusses and explains names of isotretinoin, its physical and chemical characteristics. It also includes methods of preparation, thermal and spectral behavior, methods of analysis, and pharmacology.

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异维甲酸。

异维甲酸的化学名称为:(2Z, 4E, 6E, 8E)-3,7-二甲基-9-(2,6,6-三甲基环己基-1-烯基)nona-2,4,6,8-四烯酸。它是一种口服活性维甲酸衍生物，用于治疗严重难治性结节性痤疮。它的主要作用是减少皮脂腺的大小和皮脂的产生，从而改变皮肤表面的脂质组成。使用异维甲酸1-2mg/kg/天，3-4个月，痤疮患者炎性病变清除率达60%-95%。低至0.1mg/kg/天的剂量也被证明在清除病变方面是成功的。在少数酒渣鼻患者中也看到了令人鼓舞的结果。在大多数接受异维甲酸治疗的患者中，会出现影响皮肤粘膜系统的副作用和血清甘油三酯水平升高。异维甲酸在有生育能力的妇女中是严格禁忌的。本文讨论并解释了异维甲酸的名称及其物理和化学特性。它还包括制备方法，热学和光谱行为，分析方法和药理学。

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量