Efficacy and adherence of auto-CPAP therapy in patients with obstructive sleep apnea: a prospective study.

IF 2.3

Multidisciplinary Respiratory Medicine Pub Date : 2020-01-28 DOI:10.4081/mrm.2020.468

Hang Dinh-Thi-Dieu, Anh Vo-Thi-Kim, Huong Tran-Van, Sy Duong-Quy

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引用次数: 8

Abstract

Introduction: The use of auto-continuous positive airway pressure (auto-CPAP) therapy has been recommended for subjects with moderate-to-severe obstructive sleep apnea (OSA) without significant comorbidities. This study is aimed at evaluating the efficacy and adherence of auto-CPAP therapy in subjects with OSA.

Methods: It was a perspective and descriptive study. All study subjects who had apnea-hypopnea index (AHI) > 30/h, measured by polysomnography, were included. They were treated with auto-CPAP and followed-up for 6 months for evaluating the effect of CPAP-therapy on clinical and biological features and treatment adherence.

Results: One hundred and thirty-nine subjects with severe OSA were accepted for auto-CPAP therapy at inclusion. BMI was 28.4±3.8 kg/m²; neck and abdomen circumferences were 38.2±6.4 and 85.7±11.6. Epworth and Pichot scores were 18.4±6.3 and 28.3±4.5, respectively; AHI was 39±7/h and arousal index was 39±13/h. At 6^th month, 96.4% of study subjects continued to use auto-CPAP-therapy within 6.5±2.4 h/night. There was a significant correlation between the modification (Δ) of Epworth scores and (Δ) AHI after 3 and 6 months of auto-CPAP-therapy (R=0.568 and p=0.003; R=0.745 and p=0.002; respectively). At 6^th month follow up, the main side effects of auto-CPAP were difficult sleeping, dry mouth or nose, skin marks or rashes, discomfort when breathing, and nasal congestion (36.1%, 32.0%, 20.8%, 16.0%, and 11.9%, respectively).

Conclusion: Auto-CPAP is effective in treatment of Vietnamese patients with severe OSA in short term follow up.

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阻塞性睡眠呼吸暂停患者自动cpap治疗的疗效和依从性:一项前瞻性研究。

自动持续气道正压通气(auto-CPAP)治疗已被推荐用于无明显合并症的中度至重度阻塞性睡眠呼吸暂停(OSA)患者。本研究旨在评估OSA患者auto-CPAP治疗的疗效和依从性。方法:采用透视法和描述性研究。所有通过多导睡眠描记术测量的呼吸暂停低通气指数(AHI) > 30/h的研究对象均被纳入。采用auto-CPAP治疗，随访6个月，评估cpap治疗对临床和生物学特征及治疗依从性的影响。结果:139例重度OSA患者在纳入时接受了自动cpap治疗。BMI为28.4±3.8 kg/m2;颈围为38.2±6.4，腹围为85.7±11.6。Epworth和Pichot评分分别为18.4±6.3和28.3±4.5;AHI为39±7/h，兴奋指数为39±13/h。在第6个月，96.4%的研究对象在6.5±2.4小时/晚的时间内继续使用auto- cpap治疗。auto- cpap治疗3个月和6个月后Epworth评分(Δ)与AHI (Δ)的变化有显著相关性(R=0.568和p=0.003;R=0.745, p=0.002;分别)。随访6个月时，自动cpap的主要不良反应为睡眠困难、口鼻干燥、皮肤印痕或皮疹、呼吸不适和鼻塞(分别为36.1%、32.0%、20.8%、16.0%和11.9%)。结论:在短期随访中，Auto-CPAP治疗越南重度OSA患者是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine

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期刊介绍： Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.