Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death†

Abstract

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H₂S donor micelle releases H₂S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.