Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications.

IF 2.4 Q1 PEDIATRICS
Adrian P Regensburger, Alexandra L Wagner, Jing Claussen, Maximilian J Waldner, Ferdinand Knieling
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引用次数: 12

Abstract

Optoacoustic imaging (OAI), or photoacoustic imaging (PAI), has fundamentally influenced basic science by providing high-resolution visualization of biological mechanisms. With the introduction of multispectral optoacoustic tomography (MSOT), these technologies have now moved closer to clinical applications. MSOT utilizes short-pulsed near-infrared laser light to induce thermoelastic expansion in targeted tissues. This results in acoustic pressure waves, which are used to resolve specific endo- and exogenous chromophores. Especially in the pediatric population, this non-invasive imaging approach might hold fundamental advantages compared to conventional cross-sectional imaging modalities. As this technology allows the visualization of quantitative molecular tissue composition at high spatial resolution non-invasively in sufficient penetration depth, it paves the way to personalized medicine in pediatric diseases.

Abstract Image

揭示儿科疾病:多光谱光声断层扫描在临床应用的门口。
光声成像(OAI)或光声成像(PAI)通过提供生物机制的高分辨率可视化,从根本上影响了基础科学。随着多光谱光声断层扫描(MSOT)的引入,这些技术现在已经接近临床应用。MSOT利用短脉冲近红外激光诱导靶组织的热弹性膨胀。这就产生了声压波,用于分辨特定的内和外源性发色团。特别是在儿科人群中,与传统的横断面成像方式相比,这种非侵入性成像方法可能具有根本优势。由于该技术可以在足够的穿透深度下以高空间分辨率无创地可视化定量分子组织组成,为儿科疾病的个性化医疗铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.20
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