Cetirizine use in childhood: an update of a friendly 30-year drug.

Q2 Medicine

Clinical and Molecular Allergy Pub Date : 2020-02-26 eCollection Date: 2020-01-01 DOI:10.1186/s12948-020-00118-5

Giuseppe Fabio Parisi, Salvatore Leonardi, Giorgio Ciprandi, Angelo Corsico, Amelia Licari, Michele Miraglia Del Giudice, Diego Peroni, Carmelo Salpietro, Gian Luigi Marseglia

引用次数: 12

Abstract

Cetirizine is a second-generation antihistamine, derived from the metabolism of hydroxyzine, highly specific for the H1 receptors, and with marked antiallergic properties. Although its history began more than 30 years ago, it remains one of the most used drugs in children with a leading role in the medical care of children with allergic diseases. Cetirizine use is licensed for paediatric patients for the treatment of allergic rhinitis, and chronic spontaneous urticaria, in Europe in children older than 2 years old and in the USA in children older than 6 months old. This review provides a practical update on the use of cetirizine in children and adolescents.

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西替利嗪在儿童中的使用:一种友好的30年药物的更新。

西替利嗪是由羟嗪代谢而来的第二代抗组胺药，对H1受体具有高度特异性，具有显著的抗过敏特性。虽然它的历史始于30多年前，但它仍然是儿童中使用最多的药物之一，在儿童过敏性疾病的医疗护理中起着主导作用。西替利嗪在欧洲获准用于治疗2岁以上儿童过敏性鼻炎和慢性自发性荨麻疹，在美国获准用于治疗6个月以上儿童。这篇综述提供了西替利嗪在儿童和青少年中使用的实际更新。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.