Maternal Caffeine Consumption and Racial Disparities in Fetal Telomere Length.

International Journal of MCH and AIDS Pub Date : 2020-01-01 Epub Date: 2019-12-30 DOI:10.21106/ijma.290
Isabel Griffin, Boubakari Ibrahimou, Natasha Navejar, Anjali Aggarwal, Kristopher Myers, Daniel Mauck, Korede K Yusuf, Usman J Wudil, Muktar H Aliyu, Hamisu M Salihu
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引用次数: 1

Abstract

Background and objectives: The identification of risk factors for shorter telomere length, especially during fetal development, would be important towards caffeine consumption recommendations for pregnant women on a global scale. The purpose of this study was to evaluate the association between caffeine intake and fetal telomere length as well as racial/ethnic differences in telomere length regardless of maternal caffeine consumption status.

Methods: Caffeine intake was measured using a food frequency questionnaire (FFQ). Three generalized linear models (GLM) were compared based on binary categorical variables of caffeine levels using data mean value of 117.3 mg as cut-off; the World Health Organization (WHO) recommendations of 300 mg; and the American College of Obstetricians and Gynecologists (ACOG) recommendations of 200 mg. The association between caffeine consumption and telomere length (telomere to single-copy [T/S] ratio) was then assessed.

Results: Among 57 maternal-fetal dyads, 77.2% reported less than 200 mg of caffeine (ACOG) and 89.5% less than 300 mg (WHO). Both WHO and ACOG models found that caffeine intake was significantly and positively associated with longer telomere length (p<0.05); and sodium (p<0.05). Other" race (p<0.001) and "white" race (p<0.001) were also significantly and positively associated with longer telomere length in the same models. Increasing maternal age shortened telomere length significantly in all models (p<0.001).

Conclusion and global health implications: Caffeine intake, maternal age, and race may be associated with alterations in fetal telomere length. This indicates that caffeine consumption during pregnancy may have long-term implications for fetal development. The racial/ethnic differences in telomere length found in this study warrant larger studies to further confirm these associations.

Abstract Image

Abstract Image

母体咖啡因摄入与胎儿端粒长度的种族差异。
背景和目的:确定端粒长度缩短的危险因素,特别是在胎儿发育期间,对全球范围内孕妇的咖啡因摄入量建议具有重要意义。本研究的目的是评估咖啡因摄入量与胎儿端粒长度之间的关系,以及在不考虑母体咖啡因摄入状况的情况下端粒长度的种族/民族差异。方法:采用食物频率问卷(FFQ)测量咖啡因摄入量。以数据均值117.3 mg为截止值,比较三种基于咖啡因水平二元分类变量的广义线性模型(GLM);世界卫生组织(世卫组织)建议300毫克;而美国妇产科学会(ACOG)的建议摄入量为200毫克。然后评估咖啡因摄入量与端粒长度(端粒与单拷贝[T/S]比率)之间的关系。结果:在57对母胎中,77.2%的人报告咖啡因低于200 mg (ACOG), 89.5%的人报告咖啡因低于300 mg (WHO)。WHO和ACOG模型均发现,咖啡因摄入量与端粒长度延长显著正相关(结论和全球健康影响:咖啡因摄入量、母亲年龄和种族可能与胎儿端粒长度的改变有关)。这表明孕期摄入咖啡因可能对胎儿发育有长期影响。本研究中发现的端粒长度的种族/民族差异需要更大规模的研究来进一步证实这些关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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