Preclinical Study of the Antidiabetic Effect of Traganum nudatum in Diabetic Rats.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871525718666200228113239

Fadwa El-Ouady, Mohamed Eddouks

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Abstract

Aims: The aim of the study was to study the antidiabetic effect of Traganum nudatum in an animal model of diabetes.

Background: Traganum nudatum (T. nudatum) is a medicinal plant widely used in folk medicine by the Moroccan population to treat various diseases including diabetes.

Objective: The objective of the study was to evaluate the antihyperglycemic and hypoglycemic of the aqueous Traganum nudatum extract in normal and streptozotocin-induced diabetic rats.

Methods: Normal and streptozotocin-induced diabetic rats were treated orally by the extract of Traganum nudatum (T. nudatum) at a dose of 50 mg/kg. The blood glucose levels were determined for 6 hours and 15 days during this treatment. The oral glucose tolerance and phytochemical tests and the analysis of histopathological changes of the liver were performed. The antioxidant activity of aqueous T. nudatum extract was also assessed using the method of trapping of free radical 2,2- diphenyl-1 picrylhydrazyl (DPPH).

Results: T. nudatum Aerial Part Aqueous Extract (TNAPAE) reduced the blood glucose levels in both normal and diabetic rats. The results demonstrated that TNAPAE treatment exhibited a significant hypoglycemic effect without altering the body weight. In addition, a noticeable influence on glucose tolerance was also observed after TNAPAE treatment. Moreover, TNAPAE was able to exhibit a beneficial effect on the histological structure of the liver. Finally, a potential antioxidant effect has been shown in vitro.

Conclusion: In conclusion, this study demonstrates the antihyperglycemic and hypoglycemic effects of T. nudatum in rats supporting its traditional use for the management of diabetes.

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黄芪对糖尿病大鼠抗糖尿病作用的临床前研究。

目的:研究黄芪对糖尿病动物模型的抗糖尿病作用。背景:黄豆(Traganum nudatum, T. nudatum)是一种药用植物，被摩洛哥人民广泛用于民间医学，治疗包括糖尿病在内的各种疾病。目的:研究黄芪水提物对正常及链脲佐菌素诱导的糖尿病大鼠的降糖和降糖作用。方法:采用裸豆提取物(T. nudatum) 50 mg/kg剂量口服治疗正常及链脲佐菌素诱导的糖尿病大鼠。在治疗期间的6小时和15天内测定血糖水平。进行口服糖耐量、植物化学试验及肝脏组织病理变化分析。采用吸附自由基2,2-二苯基-1苦酰肼(DPPH)的方法，对裸鼠水提物的抗氧化活性进行了评价。结果:裸藤地皮水提物(TNAPAE)对糖尿病大鼠和正常大鼠血糖均有降低作用。结果表明，TNAPAE治疗在不改变体重的情况下表现出显著的降糖效果。此外，TNAPAE治疗对糖耐量也有显著影响。此外，TNAPAE能够对肝脏的组织学结构产生有益的影响。最后，它在体外也有潜在的抗氧化作用。结论:总之，本研究证明了裸竹对大鼠的降糖和降糖作用，支持了其治疗糖尿病的传统用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.