Angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema: An updated meta-analysis.

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-01-01 DOI:10.1177/1470320319900039

Yan Zheng, Jin Huang

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引用次数: 2

Abstract

Objective: The purpose of the study was to investigate the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema.

Methods: A systematic search for relevant literature was performed in MEDLINE, CNKI, and EMBASE. The pooled odds ratios and their corresponding 95% confidence intervals were calculated in STATA 12.0 software.

Results: Seven studies, with a total of 304 patients and 564 controls, qualified for the inclusion in the analysis. There was no significant association between angiotensin-converting enzyme insertion/deletion polymorphism and high-altitude pulmonary edema risk in the total population (DD vs II: odds ratio=1.07, 95% confidence interval 0.52-2.24; DI vs II: odds ratio=1.12, 0.85-1.49; dominant model: odds ratio=1.07, 0.83-1.40; recessive model: odds ratio=0.96, 0.53-1.77). Subgroup analysis according to race also revealed no significant correlation between angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema.

Conclusions: Our findings suggest that angiotensin-converting enzyme insertion/deletion polymorphism does not contribute to the risk of high-altitude pulmonary edema. Larger, well-designed studies are required to further validate these results.

查看原文本刊更多论文

血管紧张素转换酶基因插入/缺失多态性与高原肺水肿:一项最新荟萃分析。

目的:探讨血管紧张素转换酶基因插入/缺失多态性与高原肺水肿的关系。方法:系统检索MEDLINE、CNKI、EMBASE等相关文献。合并优势比及其对应的95%置信区间在STATA 12.0软件中计算。结果:7项研究，共304例患者和564例对照，符合纳入分析的条件。在总体人群中，血管紧张素转换酶插入/缺失多态性与高原肺水肿风险之间没有显著关联(DD vs II:优势比=1.07,95%可信区间0.52-2.24;DI vs II:优势比=1.12,0.85-1.49;优势模型:优势比=1.07,0.83-1.40;隐性模型:优势比=0.96,0.53-1.77)。不同种族的亚组分析也显示血管紧张素转换酶基因插入/缺失多态性与高原肺水肿无显著相关性。结论:我们的研究结果表明，血管紧张素转换酶插入/缺失多态性与高原肺水肿的风险无关。需要更大规模、设计良好的研究来进一步验证这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.