The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome.

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Obesity Pub Date : 2020-02-10 eCollection Date: 2020-01-01 DOI:10.1155/2020/8075482

Sonia Rouatbi, Ines Ghannouchi, Rim Kammoun, Helmi Ben Saad

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引用次数: 10

Abstract

Objective: To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS.

Methods: It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (F_eNO).

Results: Obesity was confirmed for the two groups with a total sample mean value of BMI = 35.06 ± 4.68 kg/m². A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93 ± 14 vs. 79 ± 12%), an abnormal DLCO (112 ± 20 vs. 93 ± 22%), and higher bronchial inflammation (18.40 ± 9.20 vs. 31.30 ± 13.60 ppb) (p < 0.05).

Conclusion: Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation.

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伴有和不伴有阻塞性睡眠呼吸暂停低通气综合征的肥胖患者的呼吸和扩散功能障碍。

目的:分析肥胖合并或不合并OSAS时的通气和肺泡-毛细血管扩散功能障碍。方法:对48例肥胖成人(23例OSAS和25例对照)进行横断面研究。收集人体测量数据(身高、体重和身体质量指数(BMI))。所有成年人都回答了一份医学问卷，并接受了呼吸暂停低通气指数(AHI)和去饱和百分比测量的多导睡眠图或睡眠多导睡眠图。收集以下肺功能数据:肺流量和容积、一氧化碳肺传递因子(DLCO)和呼出一氧化氮(FeNO)分数。结果:两组均为肥胖，总样本均值BMI = 35.06±4.68 kg/m2。与对照组相比，OSAS患者的肺功能明显下降。事实上，与对照组相比，OSAS组有严重的限制性通气缺陷(总肺活量:93±14比79±12%)，DLCO异常(112±20比93±22%)，支气管炎症较高(18.40±9.20比31.30±13.60 ppb) (p < 0.05)。结论:肥胖合并OSAS会加重肺功能和肺泡-毛细血管弥散改变的严重程度。这可以部分解释为肺泡炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.