Topical use of tranexamic acid in primary total knee arthroplasty: a comparative study.

IF 0.4 Q4 SURGERY

Giornale di Chirurgia Pub Date : 2020-01-01

G Th Besiris, C Koutserimpas, A Karamitros, I Karaiskos, D Tsakalou, K Raptis, K Kourelis, O Paxinos, A Kotsirakis, K Vlasis

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Abstract

Introduction: Perioperative blood management represents a major issue in knee arthroplasty. The aim of the present observational study is to compare two different methods of topical tranexamic acid (TXA) administration (periarticular and intraarticular) in primary knee arthroplasty.

Patients and methods: The present is an observational comparative study. A total of 66 consecutive patients receiving topical injection of TXA after unilateral primary knee arthroplasty due to osteoarthritis were recorded. Patients were divided into two groups: group 1; periarticular injection of TXA and group 2; intraarticular injection.

Results: Transfusion rate in group 1 was found to be 15%, compared to 44% in group 2 (p-value= 0.015). In transfused patients the mean received blood units were 1.2 (SD=0.44) in group 1, compared to 1.06 (SD=0.24; p-value=0.34) in group 2. The mean hospital stay of group 1 patients was 7.94 days (SD=2.79), compared to 9.58 days (SD=3.26; p-value=0.03) in group 2.

Discussion: The main findings of the study are that statically significant higher transfusion rates, as well as longer in-hospital stay were found in the intraarticular group, when compared to the periarticular group. According to these two parameters the present study has shown that the topical periarticular TXA injection is superior to the intraarticular one. Further research is of utmost importance in order to conclude to the optimum combination of knee arthroplasty perioperative blood management.

本刊更多论文

氨甲环酸在初次全膝关节置换术中的局部应用:一项比较研究。

导言:围手术期血液管理是膝关节置换术中的一个主要问题。本观察性研究的目的是比较原发性膝关节置换术中两种不同的局部氨甲环酸(TXA)给药方法(关节周和关节内)。患者和方法:本研究为观察性比较研究。我们记录了66例因骨关节炎单侧膝关节置换术后连续接受局部注射TXA的患者。患者分为两组:第一组;关节周注射TXA和2组;intraarticular注入。结果:1组输血率为15%，2组输血率为44% (p值= 0.015)。输血患者平均输血单位为1.2 (SD=0.44)，对照组为1.06 (SD=0.24);p值=0.34)。1组患者平均住院时间为7.94天(SD=2.79)，对照组为9.58天(SD=3.26);p值=0.03)。讨论:本研究的主要发现是，与关节周组相比，关节内组输血率更高，住院时间更长。根据这两个参数，本研究表明局部关节周注射TXA优于关节内注射。进一步的研究对于得出膝关节置换术围手术期血液管理的最佳组合至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Giornale di Chirurgia SURGERY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Il Giornale di Chirurgia pubblica contributi che propongono le diverse tecniche su patologia chirurgiche di attualità. Pubblica articoli originali, casistica clinica, metodi, tecniche, terapia farmacologica pre-operatoria e post-chirurgica, ed articoli inerenti la descrizione di tecniche chirurgiche.