Assessment of Admission Time Cell Blood Count (CBC) Parameters in Predicting Post-primary Percutaneous Coronary Intervention TIMI Frame Count in Patients with ST-segment Elevation Myocardial Infarction.

Q2 Medicine

Cardiovascular and Hematological Disorders - Drug Targets Pub Date : 2020-01-01 DOI:10.2174/1871529X20666200206123118

Hossein Vakili, Isa Khaheshi, Amirsina Sharifi, Negin Nickdoost, Mohammad H Namazi, Morteza Safi, Habibollah Saadat, Saeed A Parsa, Mohammad A Akbarzadeh, Mohammadreza Naderian, Negin Yousefi, Mahin Shirazi, Mohammadreza Tabary

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引用次数: 3

Abstract

Objectives: In this study, we aimed to assess the value of admission time CBC parameters in predicting post-primary PCI corrected TIMI frame count.

Background: Recent years have witnessed a large series of studies evaluating different laboratory variables to predict no-reflow phenomenon following primary PCI (PPCI) in patients with STEMI. However, a general agreement about the most reliable predictor of the no-reflow phenomenon is challenging and also intriguing.

Methods: The current study concluded 208 consecutive patients who underwent primary PCI for ST-Elevation Myocardial Infarction (STEMI) from January 2014 to February 2016. Blood samples were obtained after taking ECG. Complete blood samples were collected and analyzed within 5 minutes from sampling. Post-PCI corrected Thrombolysis in Myocardial Infarction (TIMI) frame count was determined by one interventional cardiologist blinded to patients' clinical data. The correlation between admission time blood parameters and post-primary PCI corrected TIMI frame count in patients with STEMI were assessed.

Results: Corrected TIMI frame count was positively correlated with WBC count (R: 0.18, P-value: <0.01), neutrophil count (R: 0.34, P-value: <0.01), and platelet count (R: 0.23, P-value: <0.01) and negatively correlated with lymphocyte count (R: -0.2, P-value: <0.01). Multiple linear regression results demonstrated that corrected TIMI frame count was positively correlated with neutrophil count (P < 0·001) and platelet count (P < 0·001) and negatively correlated with lymphocyte count (p=0.004).

Conclusion: High counts of WBC, neutrophil, and platelet and low count of lymphocyte may be predictors of no-reflow in STEMI patients undergoing PPCI. The clinical significance of such predictive parameters becomes clear as we consider the treatment approach in STEMI patients. Appropriate risk stratification leads to better treatment planning and allocation of resources.

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入院时间血细胞计数(CBC)参数对st段抬高型心肌梗死患者经皮冠状动脉介入治疗后TIMI框架计数的预测价值

目的:在本研究中，我们旨在评估入院时间CBC参数在预测原发性PCI校正后TIMI帧计数中的价值。背景:近年来进行了大量的研究，评估不同的实验室变量来预测STEMI患者初次PCI (PPCI)后的无再流现象。然而，关于无回流现象最可靠的预测器的普遍共识是具有挑战性的，也是有趣的。方法:本研究总结了2014年1月至2016年2月期间连续208例因st段抬高型心肌梗死(STEMI)接受首次PCI治疗的患者。取心电图后取血样。采集完整的血液样本并在5分钟内进行分析。pci校正后的心肌梗死溶栓(TIMI)帧数由一名对患者临床数据不知情的介入性心脏病专家确定。评估STEMI患者入院时间血液参数与初次PCI校正后TIMI框架计数的相关性。结果:校正后的TIMI框架计数与WBC计数呈正相关(R: 0.18, p值:结论:WBC、中性粒细胞和血小板计数高，淋巴细胞计数低可能是STEMI患者行PPCI后无再流的预测因素。当我们考虑STEMI患者的治疗方法时，这些预测参数的临床意义变得清晰。适当的风险分层导致更好的治疗计划和资源分配。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.