Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced Myocardial Infarction in Rats.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2020-01-01 DOI:10.2174/1871525718666200206114304

Sangeethadevi Govindasami, Veera Venkata Sathibabu Uddandrao, Nivedha Raveendran, Vadivukkarasi Sasikumar

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引用次数: 26

Abstract

Background: This study determined the effect of Biochanin A (BCA) on isoproterenol (ISO) induced Myocardial Infarction (MI) in male Wistar rats.

Methods: Animals (weighing 150-180 g) were divided into four groups, with six animals in each group and pretreated with BCA (10mg/kg Body Weight [BW]) and ɑ-tocopherol (60mg/kg BW) for 30 days; and ISO (20mg/kg BW) was administrated subcutaneously on the 31st and 32nd day.

Results: ISO-induced MI rats demonstrated the significant elevation of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactate dehydrogenase, creatine kinase-MB and cardiac troponin; however, concomitant pretreatment with BCA protected the rats from cardiotoxicity caused by ISO. Activities of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase significantly reduced in the heart with ISO-induced MI. Pretreatment with BCA produced a marked reversal of these antioxidant enzymes related to MI-induced by ISO.

Conclusion: In conclusion, this study suggested that BCA exerts cardioprotective effects through modulating lipid peroxidation, enhancing antioxidants, and detoxifying enzyme systems.

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生物豆素a对异丙肾上腺素诱导的大鼠心肌梗死的治疗潜力。

背景:本研究探讨了生物茶素A (BCA)对雄性Wistar大鼠异丙肾上腺素(ISO)诱导的心肌梗死(MI)的影响。方法:将体重150 ~ 180 g的大鼠分为4组，每组6只，分别给予BCA (10mg/kg体重[BW])和生育酚(60mg/kg体重[BW])预处理30 d;第31、32天皮下注射ISO (20mg/kg BW)。结果:iso诱导心肌梗死大鼠血清谷草酰转氨酶、谷丙转氨酶、乳酸脱氢酶、肌酸激酶- mb及心肌肌钙蛋白显著升高;然而，BCA联合预处理可保护大鼠免受ISO引起的心脏毒性。抗氧化酶的活性，如超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽- s -转移酶和谷胱甘肽还原酶在心肌中显著降低，BCA预处理可以显著逆转这些抗氧化酶的活性。结论:本研究提示BCA通过调节脂质过氧化、增强抗氧化剂和解毒酶系统发挥心脏保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.