Chrysanthi Sardeli, Paul Zarogoulidis, Christoforos Kosmidis, Aikaterini Amaniti, Athanasios Katsaounis, Dimitrios Giannakidis, Charilaos Koulouris, Wolfgang Hohenforst-Schmidt, Haidong Huang, Chong Bai, Nikolaos Michalopoulos, Kosmas Tsakiridis, Konstantinos Romanidis, Panagoula Oikonomou, Konstantina Mponiou, Anastasios Vagionas, Alexandru Marian Goganau, Isaak Kesisoglou, Konstantinos Sapalidis
{"title":"Inhaled chemotherapy adverse effects: mechanisms and protection methods.","authors":"Chrysanthi Sardeli, Paul Zarogoulidis, Christoforos Kosmidis, Aikaterini Amaniti, Athanasios Katsaounis, Dimitrios Giannakidis, Charilaos Koulouris, Wolfgang Hohenforst-Schmidt, Haidong Huang, Chong Bai, Nikolaos Michalopoulos, Kosmas Tsakiridis, Konstantinos Romanidis, Panagoula Oikonomou, Konstantina Mponiou, Anastasios Vagionas, Alexandru Marian Goganau, Isaak Kesisoglou, Konstantinos Sapalidis","doi":"10.2217/lmt-2019-0007","DOIUrl":null,"url":null,"abstract":"<p><p>Lung cancer is still diagnosed at a late stage due to a lack of symptoms. Although there are novel therapies, many patients are still treated with chemotherapy. In an effort to reduce adverse effects associated with chemotherapy, inhaled administration of platinum analogs has been investigated. Inhaled administration is used as a local route in order to reduce the systemic adverse effects; however, this treatment modality has its own adverse effects. In this mini review, we present drugs that were administered as nebulized droplets or dry powder aerosols for non-small-cell lung cancer. We present the adverse effects and methods to overcome them.</p>","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/lmt-2019-0007","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/lmt-2019-0007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
Lung cancer is still diagnosed at a late stage due to a lack of symptoms. Although there are novel therapies, many patients are still treated with chemotherapy. In an effort to reduce adverse effects associated with chemotherapy, inhaled administration of platinum analogs has been investigated. Inhaled administration is used as a local route in order to reduce the systemic adverse effects; however, this treatment modality has its own adverse effects. In this mini review, we present drugs that were administered as nebulized droplets or dry powder aerosols for non-small-cell lung cancer. We present the adverse effects and methods to overcome them.
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