{"title":"Accuracy of washout rate analysis for thallium-201 single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors: A phantom study.","authors":"Masaru Ishihara, Masahisa Onoguchi, Takayuki Shibutani","doi":"10.1177/2048004019900600","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess the accuracy of washout rate (WOR) analysis for thallium-201 chloride (<sup>201</sup>Tl) single-photon emission computed tomography myocardial perfusion imaging data acquired using cadmium zinc telluride detectors and a myocardial phantom.</p><p><strong>Methods: </strong>A myocardial phantom was injected with 10.5 MBq <sup>201</sup>Tl, and 10-min acquisitions were performed at 0, 24, 46, and 62 h to accommodate natural radioactive decay over time. Global myocardial WOR (global-WOR) and regional WOR (regional-WOR, left anterior descending artery [LAD], right coronary artery [RCA], and left circumflex artery [LCX]) were analyzed between 0 and 24 h (infarction model), 0 and 46 h (ischemia model), and 0 and 62 h (normal model), respectively. We compared the calculated radioactive decay-rate as a reference standard and phantom imaging WOR (phantom-WOR).</p><p><strong>Results: </strong>Decay-rate versus phantom-WOR were 20.4% vs. 20.8% (global-WOR), 21.3% (LAD), 21.2% (RCA), and 19.7% (LCX) for the infarction model; 35.4% vs. 35.6% (global-WOR), 35.5% (LAD), 36.2% (RCA), and 35.2% (LCX) for the ischemia model; and 44.5% vs. 45.1% (global-WOR), 45.4% (LAD), 44.7% (RCA), and 43.5% (LCX) for the normal model.</p><p><strong>Conclusion: </strong>WOR analysis for <sup>201</sup>Tl single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors is a reliable analysis method.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004019900600"},"PeriodicalIF":1.5000,"publicationDate":"2020-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004019900600","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JRSM Cardiovascular Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2048004019900600","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 1
Abstract
Objective: The aim of this study was to assess the accuracy of washout rate (WOR) analysis for thallium-201 chloride (201Tl) single-photon emission computed tomography myocardial perfusion imaging data acquired using cadmium zinc telluride detectors and a myocardial phantom.
Methods: A myocardial phantom was injected with 10.5 MBq 201Tl, and 10-min acquisitions were performed at 0, 24, 46, and 62 h to accommodate natural radioactive decay over time. Global myocardial WOR (global-WOR) and regional WOR (regional-WOR, left anterior descending artery [LAD], right coronary artery [RCA], and left circumflex artery [LCX]) were analyzed between 0 and 24 h (infarction model), 0 and 46 h (ischemia model), and 0 and 62 h (normal model), respectively. We compared the calculated radioactive decay-rate as a reference standard and phantom imaging WOR (phantom-WOR).
Results: Decay-rate versus phantom-WOR were 20.4% vs. 20.8% (global-WOR), 21.3% (LAD), 21.2% (RCA), and 19.7% (LCX) for the infarction model; 35.4% vs. 35.6% (global-WOR), 35.5% (LAD), 36.2% (RCA), and 35.2% (LCX) for the ischemia model; and 44.5% vs. 45.1% (global-WOR), 45.4% (LAD), 44.7% (RCA), and 43.5% (LCX) for the normal model.
Conclusion: WOR analysis for 201Tl single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors is a reliable analysis method.