Accuracy of washout rate analysis for thallium-201 single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors: A phantom study.

IF 1.5 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
JRSM Cardiovascular Disease Pub Date : 2020-01-13 eCollection Date: 2020-01-01 DOI:10.1177/2048004019900600
Masaru Ishihara, Masahisa Onoguchi, Takayuki Shibutani
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引用次数: 1

Abstract

Objective: The aim of this study was to assess the accuracy of washout rate (WOR) analysis for thallium-201 chloride (201Tl) single-photon emission computed tomography myocardial perfusion imaging data acquired using cadmium zinc telluride detectors and a myocardial phantom.

Methods: A myocardial phantom was injected with 10.5 MBq 201Tl, and 10-min acquisitions were performed at 0, 24, 46, and 62 h to accommodate natural radioactive decay over time. Global myocardial WOR (global-WOR) and regional WOR (regional-WOR, left anterior descending artery [LAD], right coronary artery [RCA], and left circumflex artery [LCX]) were analyzed between 0 and 24 h (infarction model), 0 and 46 h (ischemia model), and 0 and 62 h (normal model), respectively. We compared the calculated radioactive decay-rate as a reference standard and phantom imaging WOR (phantom-WOR).

Results: Decay-rate versus phantom-WOR were 20.4% vs. 20.8% (global-WOR), 21.3% (LAD), 21.2% (RCA), and 19.7% (LCX) for the infarction model; 35.4% vs. 35.6% (global-WOR), 35.5% (LAD), 36.2% (RCA), and 35.2% (LCX) for the ischemia model; and 44.5% vs. 45.1% (global-WOR), 45.4% (LAD), 44.7% (RCA), and 43.5% (LCX) for the normal model.

Conclusion: WOR analysis for 201Tl single-photon emission computed tomography myocardial perfusion imaging using cadmium zinc telluride detectors is a reliable analysis method.

Abstract Image

Abstract Image

Abstract Image

碲化镉锌探测器对铊-201单光子发射计算机断层心肌灌注成像的冲洗率分析准确性:一项模拟研究。
目的:评价利用碲化镉锌探测器和心肌模体对氯化铊(201Tl)单光子发射计算机断层扫描心肌灌注成像数据进行水洗率(WOR)分析的准确性。方法:将10.5 MBq 201Tl注入心肌幻影,并在0、24、46和62 h进行10分钟采集,以适应随时间的自然放射性衰变。分别在0 ~ 24 h(梗死模型)、0 ~ 46 h(缺血模型)、0 ~ 62 h(正常模型)分析心肌整体WOR (Global -WOR)和局部WOR (regional-WOR,左前降支[LAD]、右冠状动脉[RCA]、左旋支[LCX])。我们将计算的放射性衰变率作为参考标准与幻影成像WOR (phantom-WOR)进行了比较。结果:梗死模型的坏死率为20.4%,而坏死率为20.8% (global-WOR)、21.3% (LAD)、21.2% (RCA)和19.7% (LCX);35.4%比35.6% (global-WOR), 35.5% (LAD), 36.2% (RCA)和35.2% (LCX)缺血模型;正常模型为45.1% (global-WOR)、45.4% (LAD)、44.7% (RCA)和43.5% (LCX)。结论:采用碲化镉锌探测器进行201Tl单光子发射计算机断层心肌灌注成像的WOR分析是一种可靠的分析方法。
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来源期刊
JRSM Cardiovascular Disease
JRSM Cardiovascular Disease CARDIAC & CARDIOVASCULAR SYSTEMS-
自引率
6.20%
发文量
12
审稿时长
12 weeks
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