{"title":"Chitinases: Therapeutic Scaffolds for Allergy and Inflammation.","authors":"Kirtika Madan, Mansi Madan, Swapnil Sharma, Sarvesh Paliwal","doi":"10.2174/1872213X14666200114184054","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chitinases are the evolutionary conserved glycosidic enzymes that are characterized by their ability to cleave the naturally abundant polysaccharide chitin. The potential role of chitinases has been identified in the manifestation of various allergies and inflammatory diseases. In recent years, chitinases inhibitors are emerging as an alluring area of interest for the researchers and scientists and there is a dire need for the development of potential and safe chitinase antagonists for the prophylaxis and treatment of several diseases.</p><p><strong>Objective: </strong>The present review expedites the role of chitinases and their inhibitors in inflammation and related disorders.</p><p><strong>Methods: </strong>At first, an exhaustive survey of literature and various patents available related to chitinases were carried out. Useful information on chitinases and their inhibitor was gathered from the authentic scientific databases namely SCOPUS, EMBASE, PUBMED, GOOGLE SCHOLAR, MEDLINE, EMBASE, EBSCO, WEB OF SCIENCE, etc. This information was further analyzed and compiled up to prepare the framework of the review article. The search strategy was conducted by using queries with key terms \" chitin\", \"chitinase\", \"chitotrisidase\", \"acidic mammalian chitinase\", \"chitinase inhibitors\", \"asthma\" and \"chitinases associated inflammatory disorders\", etc. The patents were searched using the key terms \"chitinases and uses thereof\", \"chitinase inhibitors\", \"chitin-chitinase associated pathological disorders\" etc. from www.google.com/patents, www.freepatentsonline.com, and www.scopus.com.</p><p><strong>Results: </strong>The present review provides a vision for apprehending human chitinases and their participation in several diseases. The patents available also signify the extended role and effectiveness of chitinase inhibitors in the prevention and treatment of various diseases viz. asthma, acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer. In this regard, extensive pre-clinical and clinical investigations are required to develop some novel, potent and selective drug molecules for the treatment of various inflammatory diseases, allergies and cancers in the foreseeable future.</p><p><strong>Conclusion: </strong>In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key and rational scaffolds in designing some novel therapeutic agents in the treatment of variety of inflammatory diseases.</p>","PeriodicalId":20960,"journal":{"name":"Recent patents on inflammation & allergy drug discovery","volume":"14 1","pages":"46-57"},"PeriodicalIF":4.2000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1872213X14666200114184054","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent patents on inflammation & allergy drug discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1872213X14666200114184054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 3
Abstract
Background: Chitinases are the evolutionary conserved glycosidic enzymes that are characterized by their ability to cleave the naturally abundant polysaccharide chitin. The potential role of chitinases has been identified in the manifestation of various allergies and inflammatory diseases. In recent years, chitinases inhibitors are emerging as an alluring area of interest for the researchers and scientists and there is a dire need for the development of potential and safe chitinase antagonists for the prophylaxis and treatment of several diseases.
Objective: The present review expedites the role of chitinases and their inhibitors in inflammation and related disorders.
Methods: At first, an exhaustive survey of literature and various patents available related to chitinases were carried out. Useful information on chitinases and their inhibitor was gathered from the authentic scientific databases namely SCOPUS, EMBASE, PUBMED, GOOGLE SCHOLAR, MEDLINE, EMBASE, EBSCO, WEB OF SCIENCE, etc. This information was further analyzed and compiled up to prepare the framework of the review article. The search strategy was conducted by using queries with key terms " chitin", "chitinase", "chitotrisidase", "acidic mammalian chitinase", "chitinase inhibitors", "asthma" and "chitinases associated inflammatory disorders", etc. The patents were searched using the key terms "chitinases and uses thereof", "chitinase inhibitors", "chitin-chitinase associated pathological disorders" etc. from www.google.com/patents, www.freepatentsonline.com, and www.scopus.com.
Results: The present review provides a vision for apprehending human chitinases and their participation in several diseases. The patents available also signify the extended role and effectiveness of chitinase inhibitors in the prevention and treatment of various diseases viz. asthma, acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer. In this regard, extensive pre-clinical and clinical investigations are required to develop some novel, potent and selective drug molecules for the treatment of various inflammatory diseases, allergies and cancers in the foreseeable future.
Conclusion: In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key and rational scaffolds in designing some novel therapeutic agents in the treatment of variety of inflammatory diseases.
背景:几丁质酶是进化上保守的糖苷酶，其特点是能够裂解天然丰富的几丁质多糖。几丁质酶的潜在作用已被确定在各种过敏和炎症性疾病的表现。近年来，几丁质酶抑制剂正成为研究人员和科学家感兴趣的一个诱人领域，迫切需要开发潜在的和安全的几丁质酶拮抗剂来预防和治疗多种疾病。目的:综述几丁质酶及其抑制剂在炎症及相关疾病中的作用。方法:首先对几丁质酶的相关文献和各种专利进行全面调查。几丁质酶及其抑制剂的有用信息从SCOPUS、EMBASE、PUBMED、GOOGLE SCHOLAR、MEDLINE、EMBASE、EBSCO、WEB OF SCIENCE等权威科学数据库中收集。对这些信息进行了进一步分析和汇编，以编写审查文章的框架。关键词为“几丁质”、“几丁质酶”、“几丁质三酸苷酶”、“酸性哺乳动物几丁质酶”、“几丁质酶抑制剂”、“哮喘”和“几丁质酶相关炎症性疾病”等。本文检索了几丁质酶及其用途、几丁质酶抑制剂、几丁质酶相关病理疾病等相关专利，检索的关键词为www.google.com/patents、www.freepatentsonline.com和www.scopus.com.Results。本文综述了几丁质酶及其在几种疾病中的作用。几丁质酶抑制剂在哮喘、急慢性炎症性疾病、自身免疫性疾病、口腔疾病、神经系统疾病、代谢疾病、肝脏疾病、多囊卵巢综合征、子宫内膜异位症和癌症等多种疾病的预防和治疗中发挥着广泛的作用和有效性。因此，在可预见的未来，需要进行广泛的临床前和临床研究，以开发一些新的、有效的和选择性的药物分子，用于治疗各种炎症性疾病、过敏和癌症。结论:综上所述，几丁质酶可作为几种炎症性疾病和过敏的潜在生物标志物进行预后和诊断，而新型几丁质酶抑制剂的设计可作为设计治疗多种炎症性疾病的新型药物的关键和合理的支架。
期刊介绍：
Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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