Prognostic gene expression profiling in melanoma: necessary steps to incorporate into clinical practice.

IF 1 Q4 ONCOLOGY

Melanoma Management Pub Date : 2019-12-17 DOI:10.2217/mmt-2019-0016

Douglas Grossman, Caroline C Kim, Rebecca I Hartman, Elizabeth Berry, Kelly C Nelson, Nwanneka Okwundu, Clara Curiel-Lewandrowski, Sancy A Leachman, Susan M Swetter

引用次数: 0

Abstract

Prognostic gene expression profiling (GEP) tests for cutaneous melanoma (CM) are not recommended in current guidelines outside of a clinical trial. However, their use is becoming more prevalent and some practitioners are using GEP tests to guide patient management. Thus, there is an urgent need to bridge this gap between test usage and clinical guideline recommendations by obtaining high-quality evidence to guide us toward best practice use of GEP testing in CM patients. We focus here on the opportunities and uncertainties associated with prognostic GEP testing in CM, review how GEP testing was incorporated into clinical care guidelines for uveal melanoma and breast cancer and discuss the role of clinical trials to determine best use in patients with CM.

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黑色素瘤预后基因表达谱分析：纳入临床实践的必要步骤。

在临床试验之外，目前的指南并不推荐对皮肤黑色素瘤（CM）进行预后基因表达谱（GEP）检测。然而，它们的使用正变得越来越普遍，一些医生正在使用基因表达谱检测来指导患者的治疗。因此，我们迫切需要获得高质量的证据，以指导我们在CM患者中使用GEP检测的最佳实践，从而弥合检测使用与临床指南建议之间的差距。在此，我们将重点关注GEP检测在中医预后方面的机遇和不确定性，回顾GEP检测是如何被纳入葡萄膜黑色素瘤和乳腺癌临床治疗指南的，并讨论临床试验在确定中医患者最佳使用方法方面的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.