Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance.

Canine genetics and epidemiology Pub Date : 2019-12-09 eCollection Date: 2019-01-01 DOI:10.1186/s40575-019-0079-y

Samantha L Fousse, William D Tyrrell, Mariellen E Dentino, Frances L Abrams, Steven L Rosenthal, Joshua A Stern

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引用次数: 5

Abstract

Background: Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. The aim of this study was to perform a heritability analysis in North American Irish Wolfhounds using phenotype data from cardiac screenings performed between 2000 and 2019 in order to determine how much of this disease can be attributed to genetics compared to environmental causes. The second aim was to determine the disease mode of inheritance to help inform prevention and breeding practices.

Results: There were 327 Irish Wolfhounds diagnosed with AF and 136 Irish Wolfhounds over 8 years of age without AF. The estimated mean (95% confidence interval) heritability of AF in Irish Wolfhounds was 0.69 (0.50-0.86). The pedigree was consistent with a dominant mode of inheritance.

Conclusion: Results of this study indicate a strong genetic contribution to AF in Irish Wolfhounds and suggest that future research to identify causative genetic mutations is warranted.

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家谱分析心房颤动在爱尔兰猎狼犬支持高遗传性与显性模式的遗传。

背景:房颤(AF)是犬类最常见的心律失常。爱尔兰猎狼犬有很高的房颤患病率，这使它们成为研究这种疾病可能的遗传贡献的理想品种。本研究的目的是利用2000年至2019年期间进行的心脏筛查的表型数据对北美爱尔兰狼犬进行遗传力分析，以确定与环境原因相比，这种疾病在多大程度上可归因于遗传。第二个目标是确定疾病的遗传模式，以帮助为预防和育种实践提供信息。结果:诊断为房颤的爱尔兰狼犬327只，8岁以上无房颤的爱尔兰狼犬136只。估计爱尔兰狼犬房颤的平均(95%置信区间)遗传率为0.69(0.50-0.86)。家谱符合显性遗传模式。结论:本研究结果表明，爱尔兰猎狼犬AF有很强的遗传贡献，并建议未来的研究确定致病基因突变是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Canine genetics and epidemiology

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13 weeks