Metabolism remodeling in pancreatic ductal adenocarcinoma.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2019-11-04 DOI:10.15698/cst2019.12.205

Jin-Tao Li, Yi-Ping Wang, Miao Yin, Qun-Ying Lei

引用次数: 16

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of death of patients with malignant cancers by 2030. Current options of PDAC treatment are limited and the five-year survival rate is less than 8%, leading to an urgent need to explore innovatively therapeutic strategies. PDAC cells exhibit extensively reprogrammed metabolism to meet their energetic and biomass demands under extremely harsh conditions. The metabolic changes are closely linked to signaling triggered by activation of oncogenes like KRAS as well as inactivation of tumor suppressors. Furthermore, tumor microenvironmental factors including extensive desmoplastic stroma reaction result in series of metabolism remodeling to facilitate PDAC development. In this review, we focus on the dysregulation of metabolism in PDAC and its surrounding microenvironment to explore potential metabolic targets in PDAC therapy.

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胰腺导管腺癌的代谢重塑。

据预测，到2030年，胰腺导管腺癌(PDAC)将成为恶性癌症患者的第二大死因。目前PDAC治疗的选择有限，5年生存率低于8%，因此迫切需要探索创新的治疗策略。PDAC细胞表现出广泛的重编程代谢，以满足其在极端恶劣条件下的能量和生物量需求。代谢变化与KRAS等癌基因的激活以及抑癌基因的失活所触发的信号密切相关。此外，肿瘤微环境因素包括广泛的结缔组织增生间质反应，导致一系列代谢重塑，促进PDAC的发展。在这篇综述中，我们将重点关注PDAC及其周围微环境的代谢失调，以探索PDAC治疗中潜在的代谢靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.