The levels of CD4+CD25+ regulatory T cells in patients with allergic rhinitis.

Allergologie Select Pub Date : 2018-09-01 eCollection Date: 2018-01-01 DOI:10.5414/ALX01782E

Y Shaoqing, C Yinjian, Y Zhiqiang, Z Ruxin, C Na, G Rongming

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引用次数: 4

Abstract

Background: The involvement of CD4⁺CD25⁺ regulatory T cells (CD4⁺CD25⁺ T_Regs) in allergic diseases was reported previously. However, it remains unclear whether CD4⁺CD25⁺ T_Regs are involved in allergic rhinitis (AR).

Methods: Fresh whole blood from 20 patients with AR and 16 healthy donors was used to investigate the frequency of CD4⁺CD25⁺ and CD4⁺CD25^hi Treg cells using flow cytometry. In addition, serum total IgE (IU/mL) levels were determined using enzyme-linked immunosorbent assays.

Results: Patients with AR had fewer CD4⁺CD25⁺ Treg cells (2.80 ± 1.36% vs. 3.94 ± 0.97%, P < 0.01) and CD4⁺CD25^hi T_Regs (1.53 ± 0·62% vs. 2.00 ± 0.52%, P < 0.05) than control subjects. The number of CD4⁺CD25⁺ and CD4⁺CD25^hi T_Regs was correlated negatively with total immunoglobulin E levels (r = -0.79, P < 0.01 and r = -0.61, P < 0.01, respectively).

Conclusion: Deficient regulatory T cells might play a role in the development of AR.

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变应性鼻炎患者CD4+CD25+调节性T细胞水平的研究

背景:CD4+CD25+调节性T细胞(CD4+CD25+ TRegs)参与过敏性疾病已有报道。然而，CD4+CD25+ treg是否参与变应性鼻炎(AR)尚不清楚。方法:采用流式细胞术检测20例AR患者新鲜全血和16例健康献血者CD4+CD25+和CD4+CD25hi Treg细胞的频率。此外，采用酶联免疫吸附法测定血清总IgE (IU/mL)水平。结果:AR患者CD4+CD25+ Treg细胞(2.80±1.36%比3.94±0.97%，P < 0.01)和CD4+CD25hi Treg细胞(1.53±0.62%比2.00±0.52%，P < 0.05)低于对照组。CD4+CD25+和CD4+CD25hi treg数量与总免疫球蛋白E水平呈负相关(r = -0.79, P < 0.01, r = -0.61, P < 0.01)。结论:调节性T细胞缺陷可能在AR的发生发展中起一定作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Allergologie Select

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