Estrogen level monitoring in artificial frozen-thawed embryo transfer cycles using step-up regime without pituitary suppression: is it necessary?

Journal of experimental & clinical assisted reproduction Pub Date : 2008-07-04 DOI:10.1186/1743-1050-5-4

Zhihong Niu, Yun Feng, Yijuan Sun, Aijun Zhang, Huiqin Zhang

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引用次数: 31

Abstract

Background: To discuss the meaning of serum oestradiol monitoring in frozen embryo transfer cycle using hormone replacement without pretreatment with gonadotropin hormone (GnRH) agonist.

Methods: The data from two hundred twelve women undergoing two hundred seventy-four frozen-thawed embryo transfer (FET) cycles was included in this retrospective cohort study. They were detected of serum oestradiol levels and endometrium thicknesses during hormone supplement FET cycles and compared their pregnancy outcomes according to their oestradiol level on progesterone initiation day.

Results: Patients with different levels of serum oestradiol (percentile 0-25th, 25th-75th and 75th-100th) on progesterone initiation day yielded the endometrium thickness of 9.3 +/- 0.12, 8.9 +/- 0.07 and 9.1 +/- 0.11 mm(P > 0.05) and the pregnancy rate of 32.2%, 38.4% and 36.3% (P > 0.05) respectively.

Conclusion: The serum estradiol level did not predict pregnancy success in hormone replacement FET cycles, suggesting that oestradiol monitoring in this method of endometrial preparation is unnecessary.

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在人工冻融胚胎移植周期中使用无垂体抑制的强化方案监测雌激素水平:有必要吗?

背景:探讨无促性腺激素(GnRH)激动剂预处理的激素替代冷冻胚胎移植周期血清雌二醇监测的意义。方法:这项回顾性队列研究纳入了来自212名接受274个冷冻解冻胚胎移植周期的妇女的数据。检测她们在激素补充FET周期内的血清雌二醇水平和子宫内膜厚度，并根据她们在黄体酮起始日的雌二醇水平比较她们的妊娠结局。结果:孕酮起始日血清雌二醇水平不同(0 ~ 25、25 ~ 75、75 ~ 100)的患者子宫内膜厚度分别为9.3 +/- 0.12、8.9 +/- 0.07、9.1 +/- 0.11 mm(P > 0.05)，妊娠率分别为32.2%、38.4%、36.3% (P > 0.05)。结论:血清雌二醇水平不能预测激素替代FET周期的妊娠成功，提示在这种子宫内膜制备方法中监测雌二醇是不必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of experimental & clinical assisted reproduction

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