Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.).

IF 2.4 Q1 PEDIATRICS
Thomas Reinehr, Dirk Schnabel, Martin Wabitsch, Susanne Bechtold-Dalla Pozza, Christoph Bührer, Bettina Heidtmann, Frank Jochum, Thomas Kauth, Antje Körner, Walter Mihatsch, Christine Prell, Silvia Rudloff, Bettina Tittel, Joachim Woelfle, Klaus-Peter Zimmer, Berthold Koletzko
{"title":"Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.).","authors":"Thomas Reinehr,&nbsp;Dirk Schnabel,&nbsp;Martin Wabitsch,&nbsp;Susanne Bechtold-Dalla Pozza,&nbsp;Christoph Bührer,&nbsp;Bettina Heidtmann,&nbsp;Frank Jochum,&nbsp;Thomas Kauth,&nbsp;Antje Körner,&nbsp;Walter Mihatsch,&nbsp;Christine Prell,&nbsp;Silvia Rudloff,&nbsp;Bettina Tittel,&nbsp;Joachim Woelfle,&nbsp;Klaus-Peter Zimmer,&nbsp;Berthold Koletzko","doi":"10.1186/s40348-019-0090-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Low vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below reference values, it is debated whether vitamin D should be supplemented after infancy.</p><p><strong>Methods: </strong>The effects of vitamin D supplementation in children > 2 years of age are analyzed based on a literature review of randomized controlled trials (RCTs).</p><p><strong>Results: </strong>Vitamin D supplementation can potentially reduce the risk for influenza infections and improve asthma bronchiale exacerbation; however, it has no impact on asthma bronchiale severity. Vitamin D supplementation has no relevant effect on attention-deficit/hyperactivity disorders, cardiac failure, hypertension, or incidence of type II diabetes mellitus. Vitamin D supplementation has no effect on the rate of multiple sclerosis relapses, but on the number of new lesions detected by MRI. For other endpoints, RCTs are lacking.</p><p><strong>Conclusion: </strong>Based on currently available studies, routine vitamin D supplementation is not be recommended for children aged > 2 years, even when they have serum concentrations below reference values. Routine vitamin D supplementation is not recommended in children who do not have risk factors and chronic diseases which are associated with calcium or vitamin D resorption disorders.</p>","PeriodicalId":74215,"journal":{"name":"Molecular and cellular pediatrics","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2019-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40348-019-0090-0","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and cellular pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40348-019-0090-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 13

Abstract

Background: Low vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below reference values, it is debated whether vitamin D should be supplemented after infancy.

Methods: The effects of vitamin D supplementation in children > 2 years of age are analyzed based on a literature review of randomized controlled trials (RCTs).

Results: Vitamin D supplementation can potentially reduce the risk for influenza infections and improve asthma bronchiale exacerbation; however, it has no impact on asthma bronchiale severity. Vitamin D supplementation has no relevant effect on attention-deficit/hyperactivity disorders, cardiac failure, hypertension, or incidence of type II diabetes mellitus. Vitamin D supplementation has no effect on the rate of multiple sclerosis relapses, but on the number of new lesions detected by MRI. For other endpoints, RCTs are lacking.

Conclusion: Based on currently available studies, routine vitamin D supplementation is not be recommended for children aged > 2 years, even when they have serum concentrations below reference values. Routine vitamin D supplementation is not recommended in children who do not have risk factors and chronic diseases which are associated with calcium or vitamin D resorption disorders.

Abstract Image

2岁后补充维生素D:营养委员会、德国儿科和青少年医学学会(DGKJ e.v.)和德国儿科内分泌学和糖尿病学会(DGKED e.v.)的联合立场。
背景:在观察性研究中,低维生素D血清浓度与佝偻病和其他疾病有关。由于儿童和青少年的维生素D血清浓度经常低于参考值,因此在婴儿期后是否应该补充维生素D一直存在争议。方法:通过随机对照试验(RCTs)的文献综述,分析维生素D补充剂对> 2岁儿童的影响。结果:补充维生素D可以潜在地降低流感感染的风险,改善哮喘支气管恶化;然而,它对支气管哮喘的严重程度没有影响。补充维生素D对注意缺陷/多动障碍、心力衰竭、高血压或II型糖尿病的发病率没有相关影响。补充维生素D对多发性硬化症的复发率没有影响,但对MRI检测到的新病变数量有影响。对于其他终点,缺乏随机对照试验。结论:根据现有的研究,不建议2岁以上的儿童常规补充维生素D,即使他们的血清浓度低于参考值。对于没有与钙或维生素D吸收障碍相关的危险因素和慢性疾病的儿童,不建议常规补充维生素D。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.20
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信