Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation?

IF 2.5 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chromosoma Pub Date : 2020-06-01 Epub Date: 2019-07-04 DOI:10.1007/s00412-019-00717-5

Harman Kaur, Pavithra Rv, Srimonta Gayen

引用次数: 7

Abstract

The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.

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人类多能干细胞中被抑制的x染色体:抑制还是消除x上调?

最近关于人类胚胎植入前x染色体抑制的报道仍然存在争议。随后，Sahakyan等人在人类naïve多能干细胞(hPSCs)中也发现了x染色体抑制的证据。在这里，我们讨论了在hPSCs中报道的X-dampening是否真实地反映了x染色体的dampening，或者它是x染色体上调被消除的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chromosoma 生物-生化与分子生物学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Chromosoma publishes research and review articles on the functional organization of the eukaryotic cell nucleus, with a particular emphasis on the structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis; the function and dynamics of subnuclear compartments; the nuclear envelope and nucleocytoplasmic interactions, and more. The scope of Chromosoma encompasses genetic, biophysical, molecular and cell biological studies. Average time from receipt of contributions to first decision: 22 days Publishes research and review articles on the functional organization of the eukaryotic cell nucleus Topics include structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis and more Encompasses genetic, biophysical, molecular and cell biological studies.