Effects of Serum Albumin Levels on Antithrombin Supplementation Outcomes Among Patients With Sepsis-Associated Coagulopathy: A Retrospective Study.

IF 3 Q2 Medicine
Clinical Medicine Insights-Blood Disorders Pub Date : 2019-06-21 eCollection Date: 2019-01-01 DOI:10.1177/1179545X19858361
Masatomo Ebina, Kazunori Fujino, Akira Inoue, Koichi Ariyoshi, Yutaka Eguchi
{"title":"Effects of Serum Albumin Levels on Antithrombin Supplementation Outcomes Among Patients With Sepsis-Associated Coagulopathy: A Retrospective Study.","authors":"Masatomo Ebina,&nbsp;Kazunori Fujino,&nbsp;Akira Inoue,&nbsp;Koichi Ariyoshi,&nbsp;Yutaka Eguchi","doi":"10.1177/1179545X19858361","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Severe sepsis is commonly associated with mortality among critically ill patients and is known to cause coagulopathy. While antithrombin is an anticoagulant used in this setting, serum albumin levels are known to influence serum antithrombin levels. Therefore, this study aimed to evaluate the outcomes of antithrombin supplementation in patients with sepsis-associated coagulopathy, as well as the relationship between serum albumin levels and the effects of antithrombin supplementation.</p><p><strong>Methods: </strong>This retrospective study evaluated patients who were >18 years of age and had been admitted to either of two intensive care units for sepsis-associated coagulopathy. The groups that did and did not receive antithrombin supplementation were compared for outcomes up to 1 year after admission. Subgroup analyses were performed for patients with serum albumin levels of <2.5 g/dL or ⩾2.5 g/dL.</p><p><strong>Results: </strong>Fifty-one patients received antithrombin supplementation and 163 patients did not. The Cox proportional hazards model revealed that antithrombin supplementation was independently associated with 28-day survival (hazard ratio [HR]: 0.374, <i>P</i> = 0.025) but not with 1 year survival (HR: 0.915, <i>P</i> = 0.752). In addition, among patients with serum albumin levels of <2.5 g/dL, antithrombin supplementation was associated with a significantly lower 28-day mortality rate (9.4% vs 36.8%, <i>P</i> = .009).</p><p><strong>Conclusion: </strong>Antithrombin supplementation may improve short-term survival, but not long-term survival, among patients with sepsis-associated coagulopathy.</p>","PeriodicalId":43083,"journal":{"name":"Clinical Medicine Insights-Blood Disorders","volume":"12 ","pages":"1179545X19858361"},"PeriodicalIF":3.0000,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179545X19858361","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine Insights-Blood Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1179545X19858361","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1

Abstract

Background: Severe sepsis is commonly associated with mortality among critically ill patients and is known to cause coagulopathy. While antithrombin is an anticoagulant used in this setting, serum albumin levels are known to influence serum antithrombin levels. Therefore, this study aimed to evaluate the outcomes of antithrombin supplementation in patients with sepsis-associated coagulopathy, as well as the relationship between serum albumin levels and the effects of antithrombin supplementation.

Methods: This retrospective study evaluated patients who were >18 years of age and had been admitted to either of two intensive care units for sepsis-associated coagulopathy. The groups that did and did not receive antithrombin supplementation were compared for outcomes up to 1 year after admission. Subgroup analyses were performed for patients with serum albumin levels of <2.5 g/dL or ⩾2.5 g/dL.

Results: Fifty-one patients received antithrombin supplementation and 163 patients did not. The Cox proportional hazards model revealed that antithrombin supplementation was independently associated with 28-day survival (hazard ratio [HR]: 0.374, P = 0.025) but not with 1 year survival (HR: 0.915, P = 0.752). In addition, among patients with serum albumin levels of <2.5 g/dL, antithrombin supplementation was associated with a significantly lower 28-day mortality rate (9.4% vs 36.8%, P = .009).

Conclusion: Antithrombin supplementation may improve short-term survival, but not long-term survival, among patients with sepsis-associated coagulopathy.

Abstract Image

Abstract Image

Abstract Image

血清白蛋白水平对败血症相关凝血病患者抗凝血酶补充结果的影响:一项回顾性研究。
背景:严重脓毒症通常与危重病人的死亡率相关,并且已知会引起凝血功能障碍。虽然抗凝血酶是在这种情况下使用的抗凝血剂,血清白蛋白水平已知会影响血清抗凝血酶水平。因此,本研究旨在评价补充抗凝血酶对脓毒症相关凝血功能障碍患者的预后,以及血清白蛋白水平与补充抗凝血酶效果的关系。方法:本回顾性研究评估了年龄>18岁且因脓毒症相关凝血病入住两间重症监护病房的患者。在入院后1年内,对服用和未服用抗凝血酶的两组进行比较。结果:51例患者补充了抗凝血酶,163例患者没有补充。Cox比例风险模型显示,抗凝血酶补充与28天生存率独立相关(风险比[HR]: 0.374, P = 0.025),但与1年生存率无关(风险比:0.915,P = 0.752)。此外,患者血清白蛋白水平P = 0.009)。结论:补充抗凝血酶可以改善败血症相关凝血病患者的短期生存,但不能改善长期生存。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.70
自引率
0.00%
发文量
0
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信